Journal Article

FZJ-2018-01739

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Advancements of the sFIDA method for oligomer-based diagnostics of neurodegenerative diseases

Kulawik, A.FZJ* ; Heise, H.FZJ* ; Zafiu, C.FZJ* ; Willbold, D.FZJ* ; Bannach, O. (Corresponding author)FZJ*

2018
Wiley Chichester

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Please use a persistent id in citations: doi:10.1002/1873-3468.12983

Abstract: Early diagnosis of Alzheimer's disease (AD) is of great importance for the development of therapeutics and their application in the clinical environment. Amyloid β (Aβ) oligomers are crucial for the onset and progression of AD and represent a popular drug target, being presumably the most direct biomarker. Efforts to measure Aβ oligomers in body fluids are hampered by the low analyte concentration and presence of Aβ monomers. The surface-based fluorescence intensity distribution analysis (sFIDA) features both highly specific and sensitive oligomer quantitation as well as total insensitivity towards monomers. In this Review, we highlight structural features of oligomeric and fibrillar Aβ. Recent advancements in sFIDA assay development have been the successful automation, adaption for additional biomarkers such as α-synuclein oligomers, and significant improvement of essential assay parameters.

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Contributing Institute(s):

1. Strukturbiochemie (ICS-6)

Research Program(s):

1. 553 - Physical Basis of Diseases (POF3-553) (POF3-553)

Appears in the scientific report 2018

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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