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@ARTICLE{Alsop:844779,
      author       = {Alsop, Richard J. and Himbert, Sebastian and Dhaliwal,
                      Alexander and Schmalzl, Karin and Rheinstädter, Maikel C.},
      title        = {{A}spirin locally disrupts the liquid-ordered phase},
      journal      = {Royal Society Open Science},
      volume       = {5},
      number       = {2},
      issn         = {2054-5703},
      address      = {London},
      publisher    = {Royal Soc. Publ.},
      reportid     = {FZJ-2018-02155},
      pages        = {171710 -},
      year         = {2018},
      abstract     = {Local structure and dynamics of lipid membranes play an
                      important role in membrane function. The diffusion of small
                      molecules, the curvature of lipids around a protein and the
                      existence of cholesterol-rich lipid domains (rafts) are
                      examples for the membrane to serve as a functional
                      interface. The collective fluctuations of lipid tails, in
                      particular, are relevant for diffusion of membrane
                      constituents and small molecules in and across membranes,
                      and for structure and formation of membrane domains. We
                      studied the effect of aspirin (acetylsalicylic acid, ASA) on
                      local structure and dynamics of membranes composed of
                      dimyristoylphosphocholine (DMPC) and cholesterol. Aspirin is
                      a common analgesic, but is also used in the treatment of
                      cholesterol. Using coherent inelastic neutron scattering
                      experiments and molecular dynamics (MD) simulations, we
                      present evidence that ASA binds to liquid-ordered, raft-like
                      domains and disturbs domain organization and dampens
                      collective fluctuations. By hydrogen-bonding to lipid
                      molecules, ASA forms ‘superfluid’ complexes with lipid
                      molecules that can organize laterally in superlattices and
                      suppress cholesterol’s ordering effect.},
      cin          = {JCNS-2 / PGI-4 / JARA-FIT / JCNS-ILL},
      ddc          = {500},
      cid          = {I:(DE-Juel1)JCNS-2-20110106 / I:(DE-Juel1)PGI-4-20110106 /
                      $I:(DE-82)080009_20140620$ / I:(DE-Juel1)JCNS-ILL-20110128},
      pnm          = {144 - Controlling Collective States (POF3-144) / 524 -
                      Controlling Collective States (POF3-524) / 6212 - Quantum
                      Condensed Matter: Magnetism, Superconductivity (POF3-621) /
                      6213 - Materials and Processes for Energy and Transport
                      Technologies (POF3-621) / 6G4 - Jülich Centre for Neutron
                      Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-144 / G:(DE-HGF)POF3-524 /
                      G:(DE-HGF)POF3-6212 / G:(DE-HGF)POF3-6213 /
                      G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-Juel1)ILL-IN12-20150421},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29515878},
      UT           = {WOS:000426465700062},
      doi          = {10.1098/rsos.171710},
      url          = {https://juser.fz-juelich.de/record/844779},
}