Journal Article

FZJ-2018-02155

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Aspirin locally disrupts the liquid-ordered phase

Alsop, R. J. ; Himbert, S. ; Dhaliwal, A. ; Schmalzl, K.FZJ* ; Rheinstädter, M. C. (Corresponding author)

2018
Royal Soc. Publ. London

This record in other databases:      

Please use a persistent id in citations: http://hdl.handle.net/2128/17930  doi:10.1098/rsos.171710

Abstract: Local structure and dynamics of lipid membranes play an important role in membrane function. The diffusion of small molecules, the curvature of lipids around a protein and the existence of cholesterol-rich lipid domains (rafts) are examples for the membrane to serve as a functional interface. The collective fluctuations of lipid tails, in particular, are relevant for diffusion of membrane constituents and small molecules in and across membranes, and for structure and formation of membrane domains. We studied the effect of aspirin (acetylsalicylic acid, ASA) on local structure and dynamics of membranes composed of dimyristoylphosphocholine (DMPC) and cholesterol. Aspirin is a common analgesic, but is also used in the treatment of cholesterol. Using coherent inelastic neutron scattering experiments and molecular dynamics (MD) simulations, we present evidence that ASA binds to liquid-ordered, raft-like domains and disturbs domain organization and dampens collective fluctuations. By hydrogen-bonding to lipid molecules, ASA forms ‘superfluid’ complexes with lipid molecules that can organize laterally in superlattices and suppress cholesterol’s ordering effect.

---

Contributing Institute(s):

1. Streumethoden (JCNS-2)
2. Streumethoden (PGI-4)
3. JARA-FIT (JARA-FIT)
4. JCNS-ILL (JCNS-ILL)

Research Program(s):

1. 144 - Controlling Collective States (POF3-144) (POF3-144)
2. 524 - Controlling Collective States (POF3-524) (POF3-524)
3. 6212 - Quantum Condensed Matter: Magnetism, Superconductivity (POF3-621) (POF3-621)
4. 6213 - Materials and Processes for Energy and Transport Technologies (POF3-621) (POF3-621)
5. 6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623) (POF3-623)

Experiment(s):

1. ILL-IN12: Cold neutron 3-axis spectrometer

Appears in the scientific report 2018

---

Database coverage:
; ; ; ; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; DOAJ Seal ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

---