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@ARTICLE{Kolasinac:844995,
      author       = {Kolasinac, Rejhana and Kleusch, Christian and Braun, Tobias
                      and Merkel, Rudolf and Csiszar, Agnes},
      title        = {{D}eciphering the {F}unctional {C}omposition of {F}usogenic
                      {L}iposomes},
      journal      = {International journal of molecular sciences},
      volume       = {19},
      number       = {2},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {FZJ-2018-02326},
      pages        = {346 -},
      year         = {2018},
      abstract     = {Cationic liposomes are frequently used as carrier particles
                      for nucleic acid delivery. The most popular formulation is
                      the equimolar mixture of two components, a cationic lipid
                      and a neutral phosphoethanolamine. Its uptake pathway has
                      been described as endocytosis. The presence of an aromatic
                      molecule as a third component strongly influences the
                      cellular uptake process and results in complete membrane
                      fusion instead of endocytosis. Here, we systematically
                      varied all three components of this lipid mixture and
                      determined how efficiently the resulting particles fused
                      with the plasma membrane of living mammalian cells. Our
                      results show that an aromatic molecule and a cationic lipid
                      component with conical molecular shape are essential for
                      efficient fusion induction. While a neutral lipid is not
                      mandatory, it can be used to control fusion efficiency and,
                      in the most extreme case, to revert the uptake mechanism
                      back to endocytosis},
      cin          = {ICS-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-7-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29364187},
      UT           = {WOS:000427527400030},
      doi          = {10.3390/ijms19020346},
      url          = {https://juser.fz-juelich.de/record/844995},
}