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@ARTICLE{Heigl:845081,
      author       = {Heigl, Raimund and Longo, M. and Stellbrink, J. and
                      Radulescu, A. and Schweins, R. and Schrader, T. E.},
      title        = {{C}rossover from a {L}inear to a {B}ranched {G}rowth
                      {R}egime in the {C}rystallization of {L}ysozyme},
      journal      = {Crystal growth $\&$ design},
      volume       = {18},
      number       = {3},
      issn         = {1528-7505},
      address      = {Washington, DC},
      publisher    = {ACS Publ.},
      reportid     = {FZJ-2018-02406},
      pages        = {1483 - 1494},
      year         = {2018},
      abstract     = {Using lysozyme as a crystallization model, existing
                      intermediate clusters and aggregates have been previously
                      identified as fractal systems using light scattering
                      techniques. However, this has not been confirmed with
                      neutron or X-ray scattering directly. In this work, we
                      attempt to deepen our knowledge of the role of the fractal
                      clusters during the crystallization process by following the
                      evolution of the fractal dimension df from the early stage
                      of the nucleation process. Indeed, three different
                      scattering techniques have been used simultaneously on the
                      same sample: dynamic light scattering, small-angle neutron
                      scattering, and static light scattering. We focused on the
                      optimal batch crystallization condition in order to obtain
                      large crystals (30 mg/mL lysozyme concentration and 3 wt
                      $\%$ sodium chloride at pD 4.75 at 298 K). The selected
                      temperature reduces the nucleation speed allowing us to
                      investigate in detail the very early stage of the
                      crystallization process. A direct temporal change of the
                      fractal dimension df during the initial growth phase of
                      lysozyme was observed with df rising from 1.0 to 1.7 in the
                      first 90 min after initiating the crystallization process.
                      The early phase of crystallization shows remarkable
                      similarities to simulations on colloid aggregation.
                      Long-term dynamic light scattering measurements allowed us
                      to gain some insight into how fractal clusters may
                      contribute during the crystal growth process. These findings
                      help to improve theoretical models of crystal growth and may
                      lead to the growth of larger crystals through a better
                      understanding of the initial nucleation phase.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6215 - Soft Matter, Health and Life Sciences (POF3-621) /
                      6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
                      / 6G15 - FRM II / MLZ (POF3-6G15)},
      pid          = {G:(DE-HGF)POF3-6215 / G:(DE-HGF)POF3-6G4 /
                      G:(DE-HGF)POF3-6G15},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000427203700027},
      doi          = {10.1021/acs.cgd.7b01433},
      url          = {https://juser.fz-juelich.de/record/845081},
}