% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@PHDTHESIS{Markov:845343,
      author       = {Markov, Aleksandr},
      title        = {{T}ailoring and {C}haracterisation of {B}ioelectronic
                      {I}nterfaces},
      volume       = {162},
      school       = {Universität Köln},
      type         = {Dr.},
      address      = {Jülich},
      publisher    = {Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag},
      reportid     = {FZJ-2018-02617},
      isbn         = {978-3-95806-298-6},
      series       = {Schriften des Forschungszentrums Jülich. Reihe
                      Schlüsseltechnologien / Key Technologies},
      pages        = {74 S.},
      year         = {2018},
      note         = {Universität Köln, Diss., 2018},
      abstract     = {An in-depth understanding of the interface between cells
                      and implantable surfaces is one of the keys for coupling
                      electrically excitable cells and bioelectronics devices.
                      Recently, different approaches for the tailoring of surface
                      properties to enhance the cell adhesion or create
                      biocompatible surfaces have been introduced. These
                      approaches aim for instance to control the cell growth or
                      stimulate and record electrical signals emanating from the
                      cell. Nevertheless, it still remains an open question how to
                      create an ideal surface in a precisely controllable way for
                      cells to couple mechanically or/and electronically to
                      various materials or electronics. Here, we first present a
                      novel in situ and extremely sensitive detection method for
                      the analysis of the electronic properties of molecular layer
                      during the molecular layer deposition using an inhouse
                      engineered and automatized molecular layer deposition (MLD)
                      setup that allows to perform all process steps including
                      surface activation, deposition of different molecules from
                      the gas phase, and the desorption of superfluous molecules,
                      resulting in the formation of a molecular selfassembled
                      monolayer (SAM) without braking the vacuum. The method not
                      only allows monitoring and optimizing the deposition of
                      organic layers but also demonstrates the high potential of
                      organic SAMs for instance in form of organic high-k layers
                      in electronic devices (e.g. 𝜀$_{SAM}$ ≃ 51 in case of
                      APTES). Second, using this method, we modified the surface
                      and surface properties of silicon oxide and polyimide by
                      growing self-assembled monolayers comprising various
                      compositions of two different molecules – APTES and GLYMO.
                      The properties of the resulting mixed molecular monolayers
                      (e.g. effective thickness, hydrophobicity, and surface
                      potential) exhibit a perfect linear dependence on the
                      composition of the molecular layer demonstrating that the
                      surface properties can be tuned with these molecular layers.
                      Third, coating the mixed molecular layers with
                      poly(L-lysine) (PLL) shows that the density of polymer which
                      is commonly used as buffer layer for cell adhesion and
                      growth, can be controlled by the composition of the organic
                      layer as well. This indicates that the method might be an
                      ideal way to optimize inorganic surfaces for bioelectronics
                      applications. Finally, we used the mixed molecular
                      self-assembled monolayers to control the growth of neuronal
                      cells and enhance the cell-chip communication. We
                      demonstrate a strongly improved cell coupling and obtained
                      high signals (up to 10 mV) for the action potential of HL-1
                      cells on multi electrode structures (MEA) covered with the
                      mixed molecular layers. Additionally to this promising
                      results in biocompatibility, the SAM covered MEAs could be
                      reused for further cells experiments which would lead to
                      increased productivity and reduced costs of the cell
                      experiments. In conclusion the novel MLD technology with in
                      situ deposition control seems to be a very powerful tool and
                      might pave the way to improved or even novel bioelectronics
                      applications ranging from bio- and molecular sensors to
                      bioelectronics platforms that allows electronic interfaces
                      with biological objects.},
      cin          = {ICS-8},
      cid          = {I:(DE-Juel1)ICS-8-20110106},
      pnm          = {899 - ohne Topic (POF3-899)},
      pid          = {G:(DE-HGF)POF3-899},
      typ          = {PUB:(DE-HGF)3 / PUB:(DE-HGF)11},
      urn          = {urn:nbn:de:0001-2018050932},
      url          = {https://juser.fz-juelich.de/record/845343},
}