Journal Article

FZJ-2018-02807

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png BrainMap VBM: An environment for structural meta-analysis

Vanasse, T. J. (Corresponding author) ; Fox, P. M. ; Barron, D. S. ; Robertson, M. ; Eickhoff, S.FZJ* ; Lancaster, J. L. ; Fox, P. T. (Corresponding author)

2018
Wiley-Liss New York, NY

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Please use a persistent id in citations: doi:10.1002/hbm.24078

Abstract: The BrainMap database is a community resource that curates peer-reviewed, coordinate-based human neuroimaging literature. By pairing the results of neuroimaging studies with their relevant meta-data, BrainMap facilitates coordinate-based meta-analysis (CBMA) of the neuroimaging literature en masse or at the level of experimental paradigm, clinical disease, or anatomic location. Initially dedicated to the functional, task-activation literature, BrainMap is now expanding to include voxel-based morphometry (VBM) studies in a separate sector, titled: BrainMap VBM. VBM is a whole-brain, voxel-wise method that measures significant structural differences between or within groups which are reported as standardized, peak x-y-z coordinates. Here we describe BrainMap VBM, including the meta-data structure, current data volume, and automated reverse inference functions (region-to-disease profile) of this new community resource. CBMA offers a robust methodology for retaining true-positive and excluding false-positive findings across studies in the VBM literature. As with BrainMap's functional database, BrainMap VBM may be synthesized en masse or at the level of clinical disease or anatomic location. As a use-case scenario for BrainMap VBM, we illustrate a trans-diagnostic data-mining procedure wherein we explore the underlying network structure of 2,002 experiments representing over 53,000 subjects through independent components analysis (ICA). To reduce data-redundancy effects inherent to any database, we demonstrate two data-filtering approaches that proved helpful to ICA. Finally, we apply hierarchical clustering analysis (HCA) to measure network- and disease-specificity. This procedure distinguished psychiatric from neurological diseases. We invite the neuroscientific community to further exploit BrainMap VBM with other modeling approaches.

Note: National Institutes of Health, Grant/AwardNumbers: MH74457, RR024387,MH084812, NS062254, AA019691,EB015314; Congressionally DirectedMedical Research Program, Grant/AwardNumbers: W81XWH0820112,W81XWH1410316; Department ofDefense, Grant/Award Number:W81XWH1320065

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 574 - Theory, modelling and simulation (POF3-574) (POF3-574)

Appears in the scientific report 2018

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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