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@ARTICLE{Coenen:848310,
      author       = {Coenen, Heinz H. and Ermert, Johannes},
      title        = {18{F}-labelling innovations and their potential for
                      clinical application},
      journal      = {Clinical and translational imaging},
      volume       = {6},
      number       = {3},
      issn         = {2281-7565},
      address      = {Berlin},
      publisher    = {Springer Milan},
      reportid     = {FZJ-2018-03555},
      pages        = {169 - 193},
      year         = {2018},
      abstract     = {An impressive variety of new methodologies for the
                      preparation of 18F-labelled tracers and ligands has appeared
                      over the last decade. Most strategies of the newly developed
                      radiofluorination methods predominantly aim at products of
                      high molar activity by ‘late-stage’ labelling of small
                      (hetero)aromatic molecules and the use of transition metals.
                      This is accompanied by the improvement of technical
                      procedures, like preparation of reactive [18F]fluoride and
                      automated syntheses. The newly introduced procedures reflect
                      a high innovative level and creativity in
                      radio(pharmaceutical) chemistry at present, which are based
                      on modern chemical methods and deep mechanistic insights.
                      Taking also automation and quality control into
                      consideration, major recently developed radiofluorination
                      methods, most of those still under development, are compiled
                      here in view of their potential for clinical PET imaging and
                      thus the ability to advance molecular imaging.},
      cin          = {INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000435539000002},
      doi          = {10.1007/s40336-018-0280-0},
      url          = {https://juser.fz-juelich.de/record/848310},
}