Journal Article

FZJ-2018-03555

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png 18F-labelling innovations and their potential for clinical application

Coenen, H. H. ; Ermert, J. (Corresponding author)FZJ*

2018
Springer Milan Berlin

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Please use a persistent id in citations: http://hdl.handle.net/2128/18973  doi:10.1007/s40336-018-0280-0

Abstract: An impressive variety of new methodologies for the preparation of 18F-labelled tracers and ligands has appeared over the last decade. Most strategies of the newly developed radiofluorination methods predominantly aim at products of high molar activity by ‘late-stage’ labelling of small (hetero)aromatic molecules and the use of transition metals. This is accompanied by the improvement of technical procedures, like preparation of reactive [18F]fluoride and automated syntheses. The newly introduced procedures reflect a high innovative level and creativity in radio(pharmaceutical) chemistry at present, which are based on modern chemical methods and deep mechanistic insights. Taking also automation and quality control into consideration, major recently developed radiofluorination methods, most of those still under development, are compiled here in view of their potential for clinical PET imaging and thus the ability to advance molecular imaging.

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Contributing Institute(s):

1. Nuklearchemie (INM-5)

Research Program(s):

1. 573 - Neuroimaging (POF3-573) (POF3-573)

Appears in the scientific report 2018

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Database coverage:
; ; SCOPUS

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