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000848432 245__ $$aIn vivo Molecular Imaging of Glutamate Carboxypeptidase II Expression in Re-endothelialisation after Percutaneous Balloon Denudation in a Rat Model
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000848432 520__ $$aThe short- and long-term success of intravascular stents depends on a proper re-endothelialisation afterthe intervention-induced endothelial denudation. The aim of this study was to evaluate the potentialof in vivo molecular imaging of glutamate carboxypeptidase II (GCPII; identical with prostate-specificmembrane antigen PSMA) expression as a marker of re-endothelialisation. Fifteen Sprague Dawleyrats underwent unilateral balloon angioplasty of the common carotid artery (CCA). Positron emissiontomography (PET) using the GCPII-targeting tracer [18F]DCFPyL was performed after 5–21 days (scan 60–120 min post injection). In two animals, the GCPII inhibitor PMPA (23 mg/kg BW) was added to the tracersolution. After PET, both CCAs were removed, dissected, and immunostained with the GCPII specificantibody YPSMA-1. Difference of GCPII expression between both CCAs was established by PCR analysis.[18F]DCFPyL uptake was significantly higher in the ipsilateral compared to the contralateral CCA with anipsi-/contralateral ratio of 1.67 ± 0.39. PMPA blocked tracer binding. The selective expression of GCPII inendothelial cells of the treated CCA was confirmed by immunohistological staining. PCR analysis verifiedthe site-specific GCPII expression. By using a molecular imaging marker of GCPII expression, we providethe first non-invasive in vivo delineation of re-endothelialisation after angioplasty.
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000848432 7001_ $$0P:(DE-Juel1)132318$$aMottaghy, Felix M.$$b1$$eCorresponding author
000848432 7001_ $$0P:(DE-HGF)0$$aSimsekyilmaz, Sakine$$b2
000848432 7001_ $$0P:(DE-HGF)0$$aBucerius, Jan$$b3
000848432 7001_ $$0P:(DE-HGF)0$$aVogt, Felix$$b4
000848432 7001_ $$0P:(DE-HGF)0$$aWinz, Oliver$$b5
000848432 7001_ $$0P:(DE-Juel1)169321$$aRicharz, Raphael$$b6
000848432 7001_ $$0P:(DE-Juel1)169356$$aKrapf, Philipp$$b7$$ufzj
000848432 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, Bernd$$b8
000848432 7001_ $$0P:(DE-HGF)0$$aZlatopolskiy, Boris D.$$b9
000848432 7001_ $$0P:(DE-HGF)0$$aMorgenroth, Agnieszka$$b10
000848432 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-018-25863-1$$gVol. 8, no. 1, p. 7411$$n1$$p7411$$tScientific reports$$v8$$x2045-2322$$y2018
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