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@ARTICLE{Endepols:848432,
      author       = {Endepols, Heike and Mottaghy, Felix M. and Simsekyilmaz,
                      Sakine and Bucerius, Jan and Vogt, Felix and Winz, Oliver
                      and Richarz, Raphael and Krapf, Philipp and Neumaier, Bernd
                      and Zlatopolskiy, Boris D. and Morgenroth, Agnieszka},
      title        = {{I}n vivo {M}olecular {I}maging of {G}lutamate
                      {C}arboxypeptidase {II} {E}xpression in
                      {R}e-endothelialisation after {P}ercutaneous {B}alloon
                      {D}enudation in a {R}at {M}odel},
      journal      = {Scientific reports},
      volume       = {8},
      number       = {1},
      issn         = {2045-2322},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {FZJ-2018-03667},
      pages        = {7411},
      year         = {2018},
      abstract     = {The short- and long-term success of intravascular stents
                      depends on a proper re-endothelialisation afterthe
                      intervention-induced endothelial denudation. The aim of this
                      study was to evaluate the potentialof in vivo molecular
                      imaging of glutamate carboxypeptidase II (GCPII; identical
                      with prostate-specificmembrane antigen PSMA) expression as a
                      marker of re-endothelialisation. Fifteen Sprague Dawleyrats
                      underwent unilateral balloon angioplasty of the common
                      carotid artery (CCA). Positron emissiontomography (PET)
                      using the GCPII-targeting tracer [18F]DCFPyL was performed
                      after 5–21 days (scan 60–120 min post injection). In two
                      animals, the GCPII inhibitor PMPA (23 mg/kg BW) was added to
                      the tracersolution. After PET, both CCAs were removed,
                      dissected, and immunostained with the GCPII specificantibody
                      YPSMA-1. Difference of GCPII expression between both CCAs
                      was established by PCR analysis.[18F]DCFPyL uptake was
                      significantly higher in the ipsilateral compared to the
                      contralateral CCA with anipsi-/contralateral ratio of 1.67
                      ± 0.39. PMPA blocked tracer binding. The selective
                      expression of GCPII inendothelial cells of the treated CCA
                      was confirmed by immunohistological staining. PCR analysis
                      verifiedthe site-specific GCPII expression. By using a
                      molecular imaging marker of GCPII expression, we providethe
                      first non-invasive in vivo delineation of
                      re-endothelialisation after angioplasty.},
      cin          = {INM-5},
      ddc          = {000},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29743623},
      UT           = {WOS:000431737300097},
      doi          = {10.1038/s41598-018-25863-1},
      url          = {https://juser.fz-juelich.de/record/848432},
}