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| 001 | 848432 | ||
| 005 | 20210129234130.0 | ||
| 024 | 7 | _ | |a 10.1038/s41598-018-25863-1 |2 doi |
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| 100 | 1 | _ | |a Endepols, Heike |0 0000-0002-6166-4818 |b 0 |
| 245 | _ | _ | |a In vivo Molecular Imaging of Glutamate Carboxypeptidase II Expression in Re-endothelialisation after Percutaneous Balloon Denudation in a Rat Model |
| 260 | _ | _ | |a London |c 2018 |b Nature Publishing Group |
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| 520 | _ | _ | |a The short- and long-term success of intravascular stents depends on a proper re-endothelialisation afterthe intervention-induced endothelial denudation. The aim of this study was to evaluate the potentialof in vivo molecular imaging of glutamate carboxypeptidase II (GCPII; identical with prostate-specificmembrane antigen PSMA) expression as a marker of re-endothelialisation. Fifteen Sprague Dawleyrats underwent unilateral balloon angioplasty of the common carotid artery (CCA). Positron emissiontomography (PET) using the GCPII-targeting tracer [18F]DCFPyL was performed after 5–21 days (scan 60–120 min post injection). In two animals, the GCPII inhibitor PMPA (23 mg/kg BW) was added to the tracersolution. After PET, both CCAs were removed, dissected, and immunostained with the GCPII specificantibody YPSMA-1. Difference of GCPII expression between both CCAs was established by PCR analysis.[18F]DCFPyL uptake was significantly higher in the ipsilateral compared to the contralateral CCA with anipsi-/contralateral ratio of 1.67 ± 0.39. PMPA blocked tracer binding. The selective expression of GCPII inendothelial cells of the treated CCA was confirmed by immunohistological staining. PCR analysis verifiedthe site-specific GCPII expression. By using a molecular imaging marker of GCPII expression, we providethe first non-invasive in vivo delineation of re-endothelialisation after angioplasty. |
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| 700 | 1 | _ | |a Mottaghy, Felix M. |0 P:(DE-Juel1)132318 |b 1 |e Corresponding author |
| 700 | 1 | _ | |a Simsekyilmaz, Sakine |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Bucerius, Jan |0 P:(DE-HGF)0 |b 3 |
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| 700 | 1 | _ | |a Morgenroth, Agnieszka |0 P:(DE-HGF)0 |b 10 |
| 773 | _ | _ | |a 10.1038/s41598-018-25863-1 |g Vol. 8, no. 1, p. 7411 |0 PERI:(DE-600)2615211-3 |n 1 |p 7411 |t Scientific reports |v 8 |y 2018 |x 2045-2322 |
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