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000850148 1001_ $$0P:(DE-HGF)0$$aRosen, Jurij$$b0
000850148 245__ $$aExtracranial Metastases of a Cerebral Glioblastoma: A Case Report and Review of the Literature
000850148 260__ $$aBasel$$bKarger$$c2018
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000850148 520__ $$aThe glioblastoma, a malignant human brain tumor, is known for its devastating intracranial progress and its dismal prognosis. Whereas treatment and research are most prominently focused on the primary tumor lesion, in recent years evidence has accumulated that points to the rare occurrence of extracranial glioblastoma metastases. We here present a case of a female patient with a known glioblastoma who was detected to harbor multiple metastases in the bones, lung, pleura, liver, mesentery, and the subcutaneous soft tissue. Pathogenetically, these metastatic lesions developed most probably after a local progression of the left temporal glioblastoma through the skull base, thus getting access to the systemic lymphatics. Similar cases of extensive glioblastoma metastization, their putative underlying mechanisms, and implications for clinical care are discussed.
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000850148 7001_ $$0P:(DE-HGF)0$$aBlau, Tobias$$b1
000850148 7001_ $$0P:(DE-HGF)0$$aGrau, Stefan J.$$b2
000850148 7001_ $$0P:(DE-HGF)0$$aBarbe, Michael T.$$b3
000850148 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon Rudolf$$b4$$ufzj
000850148 7001_ $$0P:(DE-Juel1)143792$$aGalldiks, Norbert$$b5$$eCorresponding author
000850148 773__ $$0PERI:(DE-600)2458961-5$$a10.1159/000492111$$gp. 591 - 600$$n2$$p591 - 600$$tCase reports in oncology$$v11$$x1662-6575$$y2018
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