TY  - JOUR
AU  - Rosen, Jurij
AU  - Blau, Tobias
AU  - Grau, Stefan J.
AU  - Barbe, Michael T.
AU  - Fink, Gereon Rudolf
AU  - Galldiks, Norbert
TI  - Extracranial Metastases of a Cerebral Glioblastoma: A Case Report and Review of the Literature
JO  - Case reports in oncology
VL  - 11
IS  - 2
SN  - 1662-6575
CY  - Basel
PB  - Karger
M1  - FZJ-2018-04226
SP  - 591 - 600
PY  - 2018
AB  - The glioblastoma, a malignant human brain tumor, is known for its devastating intracranial progress and its dismal prognosis. Whereas treatment and research are most prominently focused on the primary tumor lesion, in recent years evidence has accumulated that points to the rare occurrence of extracranial glioblastoma metastases. We here present a case of a female patient with a known glioblastoma who was detected to harbor multiple metastases in the bones, lung, pleura, liver, mesentery, and the subcutaneous soft tissue. Pathogenetically, these metastatic lesions developed most probably after a local progression of the left temporal glioblastoma through the skull base, thus getting access to the systemic lymphatics. Similar cases of extensive glioblastoma metastization, their putative underlying mechanisms, and implications for clinical care are discussed.
LB  - PUB:(DE-HGF)16
C6  - pmid:30283316
UR  - <Go to ISI:>//WOS:000455063400052
DO  - DOI:10.1159/000492111
UR  - https://juser.fz-juelich.de/record/850148
ER  -