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@ARTICLE{Zielinski:856428,
      author       = {Zielinski, Alexander and Linnartz, Christina and Pleschka,
                      Catharina and Dreissen, Georg and Springer, Ronald and
                      Merkel, Rudolf and Hoffmann, Bernd},
      title        = {{R}eorientation dynamics and structural interdependencies
                      of actin, microtubules and intermediate filaments upon
                      cyclic stretch application},
      journal      = {Cytoskeleton},
      volume       = {75},
      number       = {9},
      issn         = {1949-3584},
      address      = {Bognor Regis},
      publisher    = {Wiley},
      reportid     = {FZJ-2018-05827},
      pages        = {385-394},
      year         = {2018},
      abstract     = {Any cell within a tissue is constantly confronted with a
                      variety of mechanical stimuli. Sensing of these diverse
                      stimuli plays an important role in cellular regulation.
                      Besides shear stress, cells of the vascular endothelium are
                      particularly exposed to a permanent cyclic straining
                      originating from the interplay of outwards pushing blood
                      pressure and inwards acting contraction by smooth
                      musculature. Perpendicular alignment of cells as structural
                      adaptation to this condition is a basic prerequisite in
                      order to withstand deformation forces.Here, we combine live
                      cell approaches with immunocytochemical analyses on single
                      cell level to closely elucidate the mechanisms of
                      cytoskeletal realignment to cyclic strain and consolidate
                      orientation analyses of actin fibres, microtubules (MTs) and
                      vimentin. We could show that strain‐induced reorientation
                      takes place for all cytoskeletal systems. However, all
                      systems are characterized by their own, specific
                      reorientation time course with actin filaments reorienting
                      first followed by MTs and finally vimentin. Interestingly,
                      in all cases, this reorientation was faster than cell body
                      realignment which argues for an active adaptation mechanism
                      for all cytoskeletal systems. Upon actin destabilization,
                      already smallest alterations in actin kinetics massively
                      hamper cell morphology under strain and therefore overall
                      reorientation. Depolymerization of MTs just slightly
                      influences actin reorientation velocity but strongly affects
                      cell body reorientation.},
      cin          = {ICS-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-7-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30176121},
      UT           = {WOS:000451117400001},
      doi          = {10.1002/cm.21470},
      url          = {https://juser.fz-juelich.de/record/856428},
}