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000857146 1001_ $$0P:(DE-HGF)0$$aHensel, Lukas$$b0
000857146 245__ $$aFunctional Connectivity Changes of Key Regions for Motor Initiation in Parkinson’s Disease
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000857146 520__ $$aAkinesia, a cardinal symptom of Parkinson’s disease, has been linked to abnormal activation in putamen and posterior medial frontal cortex (pMFC). However, little is known whether clinical severity of akinesia is linked to dysfunctional connectivity of these regions. Using a seed-based approach, we here investigated resting-state functional connectivity (RSFC) of putamen, pMFC and primary motor cortex (M1) in 60 patients with Parkinson’s disease on regular medication and 72 healthy controls. We found that in patients putamen featured decreases of connectivity for a number of cortical and subcortical areas engaged in sensorimotor and cognitive processing. In contrast, the pMFC showed reduced connectivity with a more focal cortical network involved in higher-level motor-cognition. Finally, M1 featured a selective disruption of connectivity in a network specifically connected with M1. Correlating clinical impairment with connectivity changes revealed a relationship between akinesia and reduced RSFC between pMFC and left intraparietal lobule (IPL). Together, the present study demonstrated RSFC decreases in networks for motor initiation and execution in Parkinson’s disease. Moreover, results suggest a relationship between pMFC-IPL decoupling and the manifestation of akinetic symptoms.
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000857146 7001_ $$0P:(DE-Juel1)131684$$aHoffstaedter, Felix$$b1$$ufzj
000857146 7001_ $$0P:(DE-HGF)0$$aCaspers, Julian$$b2
000857146 7001_ $$0P:(DE-HGF)0$$aMichely, Jochen$$b3
000857146 7001_ $$0P:(DE-HGF)0$$aMathys, Christian$$b4
000857146 7001_ $$0P:(DE-HGF)0$$aHeller, Julia$$b5
000857146 7001_ $$0P:(DE-Juel1)174483$$aEickhoff, Claudia$$b6$$ufzj
000857146 7001_ $$0P:(DE-HGF)0$$aReetz, Kathrin$$b7
000857146 7001_ $$0P:(DE-HGF)0$$aSüdmeyer, Martin$$b8
000857146 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon Rudolf$$b9$$ufzj
000857146 7001_ $$0P:(DE-HGF)0$$aSchnitzler, Alfons$$b10
000857146 7001_ $$0P:(DE-Juel1)161406$$aGrefkes, Christian$$b11$$ufzj
000857146 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon$$b12$$eCorresponding author$$ufzj
000857146 773__ $$0PERI:(DE-600)1483485-6$$a10.1093/cercor/bhy259$$p383-396$$tCerebral cortex$$v29$$x1460-2199$$y2019
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