Journal Article

FZJ-2018-06390

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Functional Connectivity Changes of Key Regions for Motor Initiation in Parkinson’s Disease

Hensel, L.FZJ* ; Hoffstaedter, F.FZJ* ; Caspers, J.FZJ* ; Michely, J. ; Mathys, C. ; Heller, J.FZJ* ; Eickhoff, C.FZJ* ; Reetz, K.FZJ* ; Südmeyer, M. ; Fink, G. R.FZJ* ; Schnitzler, A. ; Grefkes, C.FZJ* ; Eickhoff, S. (Corresponding author)FZJ*

2019
Oxford Univ. Press Oxford

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Please use a persistent id in citations: http://hdl.handle.net/2128/21310  doi:10.1093/cercor/bhy259

Abstract: Akinesia, a cardinal symptom of Parkinson’s disease, has been linked to abnormal activation in putamen and posterior medial frontal cortex (pMFC). However, little is known whether clinical severity of akinesia is linked to dysfunctional connectivity of these regions. Using a seed-based approach, we here investigated resting-state functional connectivity (RSFC) of putamen, pMFC and primary motor cortex (M1) in 60 patients with Parkinson’s disease on regular medication and 72 healthy controls. We found that in patients putamen featured decreases of connectivity for a number of cortical and subcortical areas engaged in sensorimotor and cognitive processing. In contrast, the pMFC showed reduced connectivity with a more focal cortical network involved in higher-level motor-cognition. Finally, M1 featured a selective disruption of connectivity in a network specifically connected with M1. Correlating clinical impairment with connectivity changes revealed a relationship between akinesia and reduced RSFC between pMFC and left intraparietal lobule (IPL). Together, the present study demonstrated RSFC decreases in networks for motor initiation and execution in Parkinson’s disease. Moreover, results suggest a relationship between pMFC-IPL decoupling and the manifestation of akinetic symptoms.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)
2. Gehirn & Verhalten (INM-7)
3. Strukturelle und funktionelle Organisation des Gehirns (INM-1)
4. JARA-BRAIN (JARA-BRAIN)

Research Program(s):

1. 572 - (Dys-)function and Plasticity (POF3-572) (POF3-572)
2. SMHB - Supercomputing and Modelling for the Human Brain (HGF-SMHB-2013-2017) (HGF-SMHB-2013-2017)
3. HBP SGA1 - Human Brain Project Specific Grant Agreement 1 (720270) (720270)
4. HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907) (785907)

Appears in the scientific report 2019

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Database coverage:
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