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@ARTICLE{Hensel:857146,
      author       = {Hensel, Lukas and Hoffstaedter, Felix and Caspers, Julian
                      and Michely, Jochen and Mathys, Christian and Heller, Julia
                      and Eickhoff, Claudia and Reetz, Kathrin and Südmeyer,
                      Martin and Fink, Gereon Rudolf and Schnitzler, Alfons and
                      Grefkes, Christian and Eickhoff, Simon},
      title        = {{F}unctional {C}onnectivity {C}hanges of {K}ey {R}egions
                      for {M}otor {I}nitiation in {P}arkinson’s {D}isease},
      journal      = {Cerebral cortex},
      volume       = {29},
      issn         = {1460-2199},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2018-06390},
      pages        = {383-396},
      year         = {2019},
      abstract     = {Akinesia, a cardinal symptom of Parkinson’s disease, has
                      been linked to abnormal activation in putamen and posterior
                      medial frontal cortex (pMFC). However, little is known
                      whether clinical severity of akinesia is linked to
                      dysfunctional connectivity of these regions. Using a
                      seed-based approach, we here investigated resting-state
                      functional connectivity (RSFC) of putamen, pMFC and primary
                      motor cortex (M1) in 60 patients with Parkinson’s disease
                      on regular medication and 72 healthy controls. We found that
                      in patients putamen featured decreases of connectivity for a
                      number of cortical and subcortical areas engaged in
                      sensorimotor and cognitive processing. In contrast, the pMFC
                      showed reduced connectivity with a more focal cortical
                      network involved in higher-level motor-cognition. Finally,
                      M1 featured a selective disruption of connectivity in a
                      network specifically connected with M1. Correlating clinical
                      impairment with connectivity changes revealed a relationship
                      between akinesia and reduced RSFC between pMFC and left
                      intraparietal lobule (IPL). Together, the present study
                      demonstrated RSFC decreases in networks for motor initiation
                      and execution in Parkinson’s disease. Moreover, results
                      suggest a relationship between pMFC-IPL decoupling and the
                      manifestation of akinetic symptoms.},
      cin          = {INM-3 / INM-7 / INM-1 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-7-20090406 /
                      I:(DE-Juel1)INM-1-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572) / SMHB -
                      Supercomputing and Modelling for the Human Brain
                      (HGF-SMHB-2013-2017) / HBP SGA1 - Human Brain Project
                      Specific Grant Agreement 1 (720270) / HBP SGA2 - Human Brain
                      Project Specific Grant Agreement 2 (785907)},
      pid          = {G:(DE-HGF)POF3-572 / G:(DE-Juel1)HGF-SMHB-2013-2017 /
                      G:(EU-Grant)720270 / G:(EU-Grant)785907},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30418548},
      UT           = {WOS:000459518500029},
      doi          = {10.1093/cercor/bhy259},
      url          = {https://juser.fz-juelich.de/record/857146},
}