guest ::
| Home > Publications database > Functional Connectivity Changes of Key Regions for Motor Initiation in Parkinson’s Disease > print |
| Home > Publications database > Functional Connectivity Changes of Key Regions for Motor Initiation in Parkinson’s Disease > print |
| 001 | 857146 | ||
| 005 | 20220930130201.0 | ||
| 024 | 7 | _ | |a 10.1093/cercor/bhy259 |2 doi |
| 024 | 7 | _ | |a 1047-3211 |2 ISSN |
| 024 | 7 | _ | |a 1460-2199 |2 ISSN |
| 024 | 7 | _ | |a 2128/21310 |2 Handle |
| 024 | 7 | _ | |a pmid:30418548 |2 pmid |
| 024 | 7 | _ | |a WOS:000459518500029 |2 WOS |
| 024 | 7 | _ | |a altmetric:51092012 |2 altmetric |
| 037 | _ | _ | |a FZJ-2018-06390 |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Hensel, Lukas |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Functional Connectivity Changes of Key Regions for Motor Initiation in Parkinson’s Disease |
| 260 | _ | _ | |a Oxford |c 2019 |b Oxford Univ. Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1551431531_9794 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Akinesia, a cardinal symptom of Parkinson’s disease, has been linked to abnormal activation in putamen and posterior medial frontal cortex (pMFC). However, little is known whether clinical severity of akinesia is linked to dysfunctional connectivity of these regions. Using a seed-based approach, we here investigated resting-state functional connectivity (RSFC) of putamen, pMFC and primary motor cortex (M1) in 60 patients with Parkinson’s disease on regular medication and 72 healthy controls. We found that in patients putamen featured decreases of connectivity for a number of cortical and subcortical areas engaged in sensorimotor and cognitive processing. In contrast, the pMFC showed reduced connectivity with a more focal cortical network involved in higher-level motor-cognition. Finally, M1 featured a selective disruption of connectivity in a network specifically connected with M1. Correlating clinical impairment with connectivity changes revealed a relationship between akinesia and reduced RSFC between pMFC and left intraparietal lobule (IPL). Together, the present study demonstrated RSFC decreases in networks for motor initiation and execution in Parkinson’s disease. Moreover, results suggest a relationship between pMFC-IPL decoupling and the manifestation of akinetic symptoms. |
| 536 | _ | _ | |a 572 - (Dys-)function and Plasticity (POF3-572) |0 G:(DE-HGF)POF3-572 |c POF3-572 |f POF III |x 0 |
| 536 | _ | _ | |a SMHB - Supercomputing and Modelling for the Human Brain (HGF-SMHB-2013-2017) |0 G:(DE-Juel1)HGF-SMHB-2013-2017 |c HGF-SMHB-2013-2017 |f SMHB |x 1 |
| 536 | _ | _ | |a HBP SGA1 - Human Brain Project Specific Grant Agreement 1 (720270) |0 G:(EU-Grant)720270 |c 720270 |f H2020-Adhoc-2014-20 |x 2 |
| 536 | _ | _ | |a HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907) |0 G:(EU-Grant)785907 |c 785907 |f H2020-SGA-FETFLAG-HBP-2017 |x 3 |
| 588 | _ | _ | |a Dataset connected to CrossRef |
| 700 | 1 | _ | |a Hoffstaedter, Felix |0 P:(DE-Juel1)131684 |b 1 |u fzj |
| 700 | 1 | _ | |a Caspers, Julian |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Michely, Jochen |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Mathys, Christian |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Heller, Julia |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Eickhoff, Claudia |0 P:(DE-Juel1)174483 |b 6 |u fzj |
| 700 | 1 | _ | |a Reetz, Kathrin |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Südmeyer, Martin |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Fink, Gereon Rudolf |0 P:(DE-Juel1)131720 |b 9 |u fzj |
| 700 | 1 | _ | |a Schnitzler, Alfons |0 P:(DE-HGF)0 |b 10 |
| 700 | 1 | _ | |a Grefkes, Christian |0 P:(DE-Juel1)161406 |b 11 |u fzj |
| 700 | 1 | _ | |a Eickhoff, Simon |0 P:(DE-Juel1)131678 |b 12 |e Corresponding author |u fzj |
| 773 | _ | _ | |a 10.1093/cercor/bhy259 |0 PERI:(DE-600)1483485-6 |p 383-396 |t Cerebral cortex |v 29 |y 2019 |x 1460-2199 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/857146/files/invoice_bhy259.pdf |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/857146/files/reprint_12187886.pdf |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/857146/files/bhy259.pdf |y OpenAccess |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/857146/files/bhy259.pdf?subformat=pdfa |x pdfa |y OpenAccess |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/857146/files/invoice_bhy259.pdf?subformat=pdfa |x pdfa |
| 909 | C | O | |o oai:juser.fz-juelich.de:857146 |p openaire |p open_access |p OpenAPC |p driver |p VDB |p ec_fundedresources |p openCost |p dnbdelivery |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 0 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a INM-3 |0 I:(DE-HGF)0 |b 0 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 1 |6 P:(DE-Juel1)131684 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 2 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a INM-1 |0 I:(DE-HGF)0 |b 2 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 5 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a JARA Brain |0 I:(DE-HGF)0 |b 5 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 6 |6 P:(DE-Juel1)174483 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 7 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a JARA Brain |0 I:(DE-HGF)0 |b 7 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 9 |6 P:(DE-Juel1)131720 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 11 |6 P:(DE-Juel1)161406 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 12 |6 P:(DE-Juel1)131678 |
| 913 | 1 | _ | |a DE-HGF |b Key Technologies |l Decoding the Human Brain |1 G:(DE-HGF)POF3-570 |0 G:(DE-HGF)POF3-572 |2 G:(DE-HGF)POF3-500 |v (Dys-)function and Plasticity |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |
| 914 | 1 | _ | |y 2019 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a Creative Commons Attribution CC BY 4.0 |0 LIC:(DE-HGF)CCBY4 |2 HGFVOC |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b CEREB CORTEX : 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b CEREB CORTEX : 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0320 |2 StatID |b PubMed Central |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |
| 920 | _ | _ | |l yes |
| 920 | 1 | _ | |0 I:(DE-Juel1)INM-3-20090406 |k INM-3 |l Kognitive Neurowissenschaften |x 0 |
| 920 | 1 | _ | |0 I:(DE-Juel1)INM-7-20090406 |k INM-7 |l Gehirn & Verhalten |x 1 |
| 920 | 1 | _ | |0 I:(DE-Juel1)INM-1-20090406 |k INM-1 |l Strukturelle und funktionelle Organisation des Gehirns |x 2 |
| 920 | 1 | _ | |0 I:(DE-82)080010_20140620 |k JARA-BRAIN |l JARA-BRAIN |x 3 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-Juel1)INM-3-20090406 |
| 980 | _ | _ | |a I:(DE-Juel1)INM-7-20090406 |
| 980 | _ | _ | |a I:(DE-Juel1)INM-1-20090406 |
| 980 | _ | _ | |a I:(DE-82)080010_20140620 |
| 980 | _ | _ | |a APC |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | 1 | _ | |a APC |
| 980 | 1 | _ | |a FullTexts |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|