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@ARTICLE{Baumann:857586,
      author       = {Baumann, Alexander and Nebel, Adelheid and Granert, Oliver
                      and Giehl, Kathrin and Wolff, Stephan and Schmidt, Wiebke
                      and Baasch, Christin and Schmidt, Gerhard and Witt, Karsten
                      and Deuschl, Günther and Hartwigsen, Gesa and Zeuner,
                      Kirsten E. and van Eimeren, Thilo},
      title        = {{N}eural {C}orrelates of {H}ypokinetic {D}ysarthria and
                      {M}echanisms of {E}ffective {V}oice {T}reatment in
                      {P}arkinson {D}isease},
      journal      = {Neurorehabilitation and neural repair},
      volume       = {32},
      number       = {12},
      issn         = {1552-6844},
      address      = {Thousand Oaks, Calif.},
      publisher    = {Sage},
      reportid     = {FZJ-2018-06571},
      pages        = {1055 –1066},
      year         = {2018},
      abstract     = {Background. Hypokinetic dysarthria is highly prevalent in
                      idiopathic Parkinson disease (PD), and effectiveness of
                      high-intensity voice treatment is well established. However,
                      the neural correlates remain largely unknown. Objective. We
                      aimed to specify cerebral pathophysiology of hypokinetic
                      dysarthria and treatment-induced changes using functional
                      magnetic resonance imaging (fMRI). Methods. We used fMRI to
                      investigate healthy controls (HCs) and patients with
                      idiopathic PD–associated dysarthria before and after
                      treatment according to the Lee Silverman Voice Treatment
                      LOUD (LSVT). During fMRI, participants covertly read
                      sentences with normal (eg, conversation in a quiet room) or
                      high (eg, shouting on a windy beach) intensity. In addition,
                      we tested LSVT effects on intelligibility and different
                      speech features (intensity, pitch, articulation). Results.
                      LSVT effectively improved intelligibility, articulation, and
                      pitch in patients. Covert high-intensity speech compared
                      with covert normal-intensity speech led to increased
                      activation of mainly secondary motor areas and bilateral
                      superior and medial temporal regions. Prior to LSVT,
                      patients showed less activity in several speech-associated
                      areas compared with HCs. As a neural correlate of effective
                      LSVT, increased right-sided superior temporal activity
                      correlated with improved intelligibility. Conclusion. This
                      is the first brain imaging study using a covert speech
                      paradigm in PD, which revealed cortical hypoactivation as
                      correlate of hypokinetic dysarthria. Furthermore, cortical
                      correlates of effective LSVT treatment colocalized with the
                      neuronal network, showing increased activation during high-
                      versus normal-intensity speech generation.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30444176},
      UT           = {WOS:000454134600005},
      doi          = {10.1177/1545968318812726},
      url          = {https://juser.fz-juelich.de/record/857586},
}