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@ARTICLE{Achtsnicht:859131,
      author       = {Achtsnicht, Stefan and Tödter, Julia and Niehues, Julia
                      and Telöken, Matthias and Offenhäusser, Andreas and
                      Krause, Hans-Joachim and Schröper, Florian},
      title        = {3{D} {P}rinted {M}odular {I}mmunofiltration {C}olumns for
                      {F}requency {M}ixing-{B}ased {M}ultiplex {M}agnetic
                      {I}mmunodetection},
      journal      = {Sensors},
      volume       = {19},
      number       = {1},
      issn         = {1424-8220},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2019-00067},
      pages        = {148 -},
      year         = {2019},
      abstract     = {For performing point-of-care molecular diagnostics,
                      magnetic immunoassays constitute a promising alternative to
                      established enzyme-linked immunosorbent assays (ELISA)
                      because they are fast, robust and sensitive. Simultaneous
                      detection of multiple biomolecular targets from one body
                      fluid sample is desired. The aim of this work is to show
                      that multiplex magnetic immunodetection based on magnetic
                      frequency mixing by means of modular immunofiltration
                      columns prepared for different targets is feasible. By
                      calculations of the magnetic response signal, the required
                      spacing between the modules was determined. Immunofiltration
                      columns were manufactured by 3D printing and antibody
                      immobilization was performed in a batch approach. It was
                      shown experimentally that two different target molecules in
                      a sample solution could be individually detected in a single
                      assaying step with magnetic measurements of the
                      corresponding immobilization filters. The arrangement order
                      of the filters and of a negative control did not influence
                      the results. Thus, a simple and reliable approach to
                      multi-target magnetic immunodetection was demonstrated.},
      cin          = {ICS-8},
      ddc          = {620},
      cid          = {I:(DE-Juel1)ICS-8-20110106},
      pnm          = {553 - Physical Basis of Diseases (POF3-553) / 523 -
                      Controlling Configuration-Based Phenomena (POF3-523)},
      pid          = {G:(DE-HGF)POF3-553 / G:(DE-HGF)POF3-523},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30609859},
      UT           = {WOS:000458574600148},
      doi          = {10.3390/s19010148},
      url          = {https://juser.fz-juelich.de/record/859131},
}