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@ARTICLE{Knig:859227,
      author       = {König, Anna and Schölzel, Daniel and Uluca, Boran and
                      Viennet, Thibault and Akbey, Ümit and Heise, Henrike},
      title        = {{H}yperpolarized {MAS} {NMR} of unfolded and misfolded
                      proteins},
      journal      = {Solid state nuclear magnetic resonance},
      volume       = {98},
      issn         = {0926-2040},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science [[-2000]]},
      reportid     = {FZJ-2019-00108},
      pages        = {1-11},
      year         = {2019},
      abstract     = {In this article we give an overview over the use of
                      DNP-enhanced solid-state NMR spectroscopy for the
                      investigation of unfolded, disordered and misfolded
                      proteins. We first provide an overview over studies in which
                      DNP spectroscopy has successfully been applied for the
                      structural investigation of well-folded amyloid fibrils
                      formed by short peptides as well as full-length proteins.
                      Sample cooling to cryogenic temperatures often leads to
                      severe line-broadening of resonance signals and thus a loss
                      in resolution. However, inhomogeneous line-broadening at low
                      temperatures provides valuable information about residual
                      dynamics and flexibility in proteins, and, in combination
                      with appropriate selective isotope labeling techniques,
                      inhomogeneous line-widths in disordered proteins or protein
                      regions may be exploited for evaluation of conformational
                      ensembles. In the last paragraph we highlight some recent
                      studies where DNP-enhanced MAS-NMR-spectroscopy was applied
                      to the study of disordered proteins/protein regions and
                      inhomogeneous sample preparations.},
      cin          = {ICS-6},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30641444},
      UT           = {WOS:000458528900001},
      doi          = {10.1016/j.ssnmr.2018.12.003},
      url          = {https://juser.fz-juelich.de/record/859227},
}