Contribution to a book

FZJ-2019-00119

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Interaction of Particles and Pathogens with Biological Membranes

Auth, T. (Corresponding author)FZJ* ; Dasgupta, S. ; Gompper, G.FZJ*

2018
Springer International Publishing Cham

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Please use a persistent id in citations: doi:10.1007/978-3-030-00630-3_17

Abstract: Biological membranes are both barriers and communication interfaces of cells. Transport across membranes is therefore essential for life. It encompasses both endocytotic and exocytotic processes important for cell function, but also the invasion of cells by parasites and viruses, and targeted drug delivery. Whereas interactions on the molecular scale are important for particles with sizes comparable with the thickness of the membrane, the mechanical properties of the entire membrane determine its interaction with larger particles. We focus here on large particles and parasites and discuss wrapping of single particles by homogeneous and complex membranes. Both solid particles with various shapes as well as soft particles are considered. Membrane-mediated interactions of many particles lead to aggregation and tubulation. Finally, active biological mechanisms are shown to support the invasion of parasites, such as the malaria parasite, and to drive phagocytosis.

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Contributing Institute(s):

1. Theorie der Weichen Materie und Biophysik (ICS-2)

Research Program(s):

1. 552 - Engineering Cell Function (POF3-552) (POF3-552)

Appears in the scientific report 2018

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