TY  - JOUR
AU  - Hammes, Jochen
AU  - Hohberg, Melanie
AU  - Täger, Philipp
AU  - Wild, Markus
AU  - Zlatopolskiy, Boris
AU  - Krapf, Philipp
AU  - Neumaier, Bernd
AU  - Schomäcker, Klaus
AU  - Kobe, Carsten
AU  - Schmidt, Matthias
AU  - Dietlein, Markus
AU  - Drzezga, Alexander
TI  - Uptake in non-affected bone tissue does not differ between [18F]-DCFPyL and [68Ga]-HBED-CC PSMA PET/CT
JO  - PLOS ONE
VL  - 13
IS  - 12
SN  - 1932-6203
CY  - San Francisco, California, US
PB  - PLOS
M1  - FZJ-2019-00145
SP  - e0209613 -
PY  - 2018
AB  - [68Ga]PSMA-HBED-CC and[18F]DCFPyL show a high potential for the detection of recurrent prostate cancer. While 18F-based tracers have several advantages in availability and image resolution, their sensitivity in the skeleton might be impaired by released [18F]fluoride due to its high bone affinity. In turn, chemically unbound trivalent 68Ga might also accumulate in osseous tissue, in cases of occupied binding sites of plasma proteins and thereby influence bone signal.
LB  - PUB:(DE-HGF)16
C6  - pmid:30571794
UR  - <Go to ISI:>//WOS:000453841700090
DO  - DOI:10.1371/journal.pone.0209613
UR  - https://juser.fz-juelich.de/record/859273
ER  -