Journal Article

FZJ-2019-00145

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Uptake in non-affected bone tissue does not differ between [18F]-DCFPyL and [68Ga]-HBED-CC PSMA PET/CT

Hammes, J. (Corresponding author) ; Hohberg, M. ; Täger, P. ; Wild, M. ; Zlatopolskiy, B.FZJ* ; Krapf, P.FZJ* ; Neumaier, B.FZJ* ; Schomäcker, K. ; Kobe, C. ; Schmidt, M.FZJ* ; Dietlein, M. ; Drzezga, A.FZJ*

2018
PLOS San Francisco, California, US

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Please use a persistent id in citations: http://hdl.handle.net/2128/21302  doi:10.1371/journal.pone.0209613

Abstract: [68Ga]PSMA-HBED-CC and[18F]DCFPyL show a high potential for the detection of recurrent prostate cancer. While 18F-based tracers have several advantages in availability and image resolution, their sensitivity in the skeleton might be impaired by released [18F]fluoride due to its high bone affinity. In turn, chemically unbound trivalent 68Ga might also accumulate in osseous tissue, in cases of occupied binding sites of plasma proteins and thereby influence bone signal.

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Contributing Institute(s):

1. Nuklearchemie (INM-5)
2. Molekulare Organisation des Gehirns (INM-2)

Research Program(s):

1. 573 - Neuroimaging (POF3-573) (POF3-573)

Appears in the scientific report 2018

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Database coverage:
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