Journal Article

FZJ-2019-01372

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png EuroInf 2: Subthalamic stimulation, apomorphine, and levodopa infusion in Parkinson's disease

Dafsari, H. S. (Corresponding author) ; Martinez‐Martin, P. ; Rizos, A. ; Trost, M. ; Santos Ghilardi, M. G. ; Reddy, P. ; Sauerbier, A. ; Petry‐Schmelzer, J. N. ; Kramberger, M. ; Borgemeester, R. W. K. ; Barbe, M. T. ; Ashkan, K. ; Silverdale, M. ; Evans, J. ; Odin, P. ; Fonoff, E. T. ; Fink, G. R.FZJ* ; Henriksen, T. ; Ebersbach, G. ; Pirtošek, Z. ; Visser‐Vandewalle, V. ; Antonini, A. ; Timmermann, L. ; Ray Chaudhuri, K. (Corresponding author)

2019
Wiley New York, NY

This record in other databases:      

Please use a persistent id in citations: doi:10.1002/mds.27626

Abstract: ObjectiveReal‐life observational report of clinical efficacy of bilateral subthalamic stimulation (STN‐DBS), apomorphine (APO), and intrajejunal levodopa infusion (IJLI) on quality of life, motor, and nonmotor symptoms (NMS) in Parkinson's disease (PD).MethodsIn this prospective, multicenter, international, real‐life cohort observation study of 173 PD patients undergoing STN‐DBS (n = 101), IJLI (n = 33), or APO (n = 39) were followed‐up using PDQuestionnaire‐8, NMSScale (NMSS), Unified PD Rating Scale (UPDRS)‐III, UPDRS‐IV, and levodopa equivalent daily dose (LEDD) before and 6 months after intervention. Outcome changes were analyzed with Wilcoxon signed‐rank or paired t test when parametric tests were applicable. Multiple comparisons were corrected (multiple treatments/scales). Effect strengths were quantified with relative changes, effect size, and number needed to treat. Analyses were computed before and after propensity score matching, balancing demographic and clinical characteristics.ResultsIn all groups, PDQuestionnaire‐8, UPDRS‐IV, and NMSS total scores improved significantly at follow‐up. Levodopa equivalent daily dose was significantly reduced after STN‐DBS. Explorative NMSS domain analyses resulted in distinct profiles: STN‐DBS improved urinary/sexual functions, mood/cognition, sleep/fatigue, and the miscellaneous domain. IJLI improved the 3 latter domains and gastrointestinal symptoms. APO improved mood/cognition, perceptual problems/hallucinations, attention/memory, and the miscellaneous domain. Overall, STN‐DBS and IJLI seemed favorable for NMSS total score, and APO favorable for neuropsychological/neuropsychiatric NMS and PDQuestionnaire‐8 outcome.ConclusionsThis is the first comparison of quality of life, nonmotor. and motor outcomes in PD patients undergoing STN‐DBS, IJLI, and APO in a real‐life cohort. Distinct effect profiles were identified for each treatment option. Our results highlight the importance of holistic nonmotor and motor symptoms assessments to personalize treatment choices. © 2019 International Parkinson and Movement Disorder Society

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 572 - (Dys-)function and Plasticity (POF3-572) (POF3-572)

Appears in the scientific report 2019

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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