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@ARTICLE{Chien:860771,
      author       = {Chien, Wei and Henry, Ewan and Fedosov, Dmitry and Gompper,
                      Gerhard},
      title        = {{S}harp-edged geometric obstacles in microfluidics promote
                      deformability-based sorting of cells},
      journal      = {Physical review fluids},
      volume       = {4},
      number       = {2},
      issn         = {2469-990X},
      address      = {College Park, MD},
      publisher    = {APS},
      reportid     = {FZJ-2019-01434},
      pages        = {024201-1},
      year         = {2019},
      abstract     = {Sorting cells based on their intrinsic properties is a
                      highly desirable objective, since changes in cell
                      deformability are often associated with various stress
                      conditions and diseases. Deterministic lateral displacement
                      (DLD) devices offer high precision for rigid spherical
                      particles, while their success in sorting deformable
                      particles remains limited due to the complexity of cell
                      traversal in DLDs. We employ mesoscopic hydrodynamics
                      simulations and demonstrate prominent advantages of
                      sharp-edged DLD obstacles for probing deformability
                      properties of red blood cells (RBCs). By consecutive
                      sharpening of the pillar shape from circular to diamond to
                      triangular geometry, a pronounced cell bending around an
                      edge is achieved, serving as a deformability sensor. Bending
                      around the edge is the primary mechanism, which governs the
                      traversal of RBCs through such DLD device. This strategy
                      requires an appropriate degree of cell bending by fluid
                      stresses, which can be controlled by the flow rate, and
                      exhibits good sensitivity to moderate changes in cell
                      deformability. We expect that similar mechanisms should be
                      applicable for the development of novel DLD devices that
                      target intrinsic properties of many other cells.},
      cin          = {ICS-2 / JARA-HPC},
      ddc          = {530},
      cid          = {I:(DE-Juel1)ICS-2-20110106 / $I:(DE-82)080012_20140620$},
      pnm          = {552 - Engineering Cell Function (POF3-552) / Blood flow in
                      microvascular networks $(jics21_20181101)$},
      pid          = {G:(DE-HGF)POF3-552 / $G:(DE-Juel1)jics21_20181101$},
      typ          = {PUB:(DE-HGF)16},
      eprint       = {1901.03863},
      howpublished = {arXiv:1901.03863},
      archivePrefix = {arXiv},
      SLACcitation = {$\%\%CITATION$ = $arXiv:1901.03863;\%\%$},
      UT           = {WOS:000458850500002},
      doi          = {10.1103/PhysRevFluids.4.024201},
      url          = {https://juser.fz-juelich.de/record/860771},
}