Journal Article

FZJ-2019-01434

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Sharp-edged geometric obstacles in microfluidics promote deformability-based sorting of cells

Chien, W.FZJ* ; Henry, E.FZJ* ; Fedosov, D. (Corresponding author)FZJ* ; Gompper, G. (Corresponding author)FZJ*

2019
APS College Park, MD

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Please use a persistent id in citations: http://hdl.handle.net/2128/21936  doi:10.1103/PhysRevFluids.4.024201

Abstract: Sorting cells based on their intrinsic properties is a highly desirable objective, since changes in cell deformability are often associated with various stress conditions and diseases. Deterministic lateral displacement (DLD) devices offer high precision for rigid spherical particles, while their success in sorting deformable particles remains limited due to the complexity of cell traversal in DLDs. We employ mesoscopic hydrodynamics simulations and demonstrate prominent advantages of sharp-edged DLD obstacles for probing deformability properties of red blood cells (RBCs). By consecutive sharpening of the pillar shape from circular to diamond to triangular geometry, a pronounced cell bending around an edge is achieved, serving as a deformability sensor. Bending around the edge is the primary mechanism, which governs the traversal of RBCs through such DLD device. This strategy requires an appropriate degree of cell bending by fluid stresses, which can be controlled by the flow rate, and exhibits good sensitivity to moderate changes in cell deformability. We expect that similar mechanisms should be applicable for the development of novel DLD devices that target intrinsic properties of many other cells.

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Contributing Institute(s):

1. Theorie der Weichen Materie und Biophysik (ICS-2)
2. JARA - HPC (JARA-HPC)

Research Program(s):

1. 552 - Engineering Cell Function (POF3-552) (POF3-552)
2. Blood flow in microvascular networks (jics21_20181101) (jics21_20181101)

Appears in the scientific report 2019

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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