%0 Journal Article
%A Brandt, Marie R.
%A Vanasschen, Christian
%A Ermert, Johannes
%A Coenen, Heinz H.
%A Neumaier, Bernd
%T 52g/55Mn-Labelled CDTA-based trimeric complexes as novel bimodal PET/MR probes with high relaxivity
%J Dalton transactions
%V 48
%N 9
%@ 0300-9246
%C London
%I Soc.
%M FZJ-2019-01710
%P 3003 - 3008
%D 2019
%X Trans-1,2-diaminocyclohexane-N,N,N‘,N‘-tetraacetic acid (CDTA) labelled with a mixture of paramagnetic 55Mn(II) and β+-emitting 52gMn(II) offers access to bimodal Positron Emission Tomography /Magnetic Resonance (PET/MR) tracers. To enhance the number of NMR-active nuclei and simultaneously improve the longitudinal relaxivity r1, a complex composed of three CDTA units was designed. Accordingly, a functionalised tris-CDTA-1,3,5-tris-triazolobenzene was prepared and labelled with c.a. and n.c.a. 52gMn. Relaxivity measurements of the 55Mn-complex showed an enhancement of r1 of 144% in comparison to the Mn-CDTA monomer. Moreover, the trimer was equipped with an additional linker functionality suitable for conjugation with biomolecules, enabling interaction with specific molecular targets.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30747205
%U <Go to ISI:>//WOS:000460780300020
%R 10.1039/C8DT04996C
%U https://juser.fz-juelich.de/record/861160