Journal Article

FZJ-2019-01710

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png 52g/55Mn-Labelled CDTA-based trimeric complexes as novel bimodal PET/MR probes with high relaxivity

Brandt, M. R.FZJ* ; Vanasschen, C.FZJ* ; Ermert, J. (Corresponding author)FZJ* ; Coenen, H. H.FZJ* ; Neumaier, B.FZJ*

2019
Soc. London

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Please use a persistent id in citations: doi:10.1039/C8DT04996C

Abstract: Trans-1,2-diaminocyclohexane-N,N,N‘,N‘-tetraacetic acid (CDTA) labelled with a mixture of paramagnetic 55Mn(II) and β+-emitting 52gMn(II) offers access to bimodal Positron Emission Tomography /Magnetic Resonance (PET/MR) tracers. To enhance the number of NMR-active nuclei and simultaneously improve the longitudinal relaxivity r1, a complex composed of three CDTA units was designed. Accordingly, a functionalised tris-CDTA-1,3,5-tris-triazolobenzene was prepared and labelled with c.a. and n.c.a. 52gMn. Relaxivity measurements of the 55Mn-complex showed an enhancement of r1 of 144% in comparison to the Mn-CDTA monomer. Moreover, the trimer was equipped with an additional linker functionality suitable for conjugation with biomolecules, enabling interaction with specific molecular targets.

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Contributing Institute(s):

1. Nuklearchemie (INM-5)

Research Program(s):

1. 573 - Neuroimaging (POF3-573) (POF3-573)

Appears in the scientific report 2019

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Database coverage:
; Allianz-Lizenz / DFG ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; National-Konsortium ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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