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000861160 1001_ $$0P:(DE-Juel1)162273$$aBrandt, Marie R.$$b0
000861160 245__ $$a52g/55Mn-Labelled CDTA-based trimeric complexes as novel bimodal PET/MR probes with high relaxivity
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000861160 520__ $$aTrans-1,2-diaminocyclohexane-N,N,N‘,N‘-tetraacetic acid (CDTA) labelled with a mixture of paramagnetic 55Mn(II) and β+-emitting 52gMn(II) offers access to bimodal Positron Emission Tomography /Magnetic Resonance (PET/MR) tracers. To enhance the number of NMR-active nuclei and simultaneously improve the longitudinal relaxivity r1, a complex composed of three CDTA units was designed. Accordingly, a functionalised tris-CDTA-1,3,5-tris-triazolobenzene was prepared and labelled with c.a. and n.c.a. 52gMn. Relaxivity measurements of the 55Mn-complex showed an enhancement of r1 of 144% in comparison to the Mn-CDTA monomer. Moreover, the trimer was equipped with an additional linker functionality suitable for conjugation with biomolecules, enabling interaction with specific molecular targets.
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000861160 7001_ $$0P:(DE-Juel1)157902$$aVanasschen, Christian$$b1
000861160 7001_ $$0P:(DE-Juel1)131818$$aErmert, Johannes$$b2$$eCorresponding author
000861160 7001_ $$00000-0002-3810-103X$$aCoenen, Heinz H.$$b3
000861160 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, Bernd$$b4
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