TY  - JOUR
AU  - Brandt, Marie R.
AU  - Vanasschen, Christian
AU  - Ermert, Johannes
AU  - Coenen, Heinz H.
AU  - Neumaier, Bernd
TI  - 52g/55Mn-Labelled CDTA-based trimeric complexes as novel bimodal PET/MR probes with high relaxivity
JO  - Dalton transactions
VL  - 48
IS  - 9
SN  - 0300-9246
CY  - London
PB  - Soc.
M1  - FZJ-2019-01710
SP  - 3003 - 3008
PY  - 2019
AB  - Trans-1,2-diaminocyclohexane-N,N,N‘,N‘-tetraacetic acid (CDTA) labelled with a mixture of paramagnetic 55Mn(II) and β+-emitting 52gMn(II) offers access to bimodal Positron Emission Tomography /Magnetic Resonance (PET/MR) tracers. To enhance the number of NMR-active nuclei and simultaneously improve the longitudinal relaxivity r1, a complex composed of three CDTA units was designed. Accordingly, a functionalised tris-CDTA-1,3,5-tris-triazolobenzene was prepared and labelled with c.a. and n.c.a. 52gMn. Relaxivity measurements of the 55Mn-complex showed an enhancement of r1 of 144% in comparison to the Mn-CDTA monomer. Moreover, the trimer was equipped with an additional linker functionality suitable for conjugation with biomolecules, enabling interaction with specific molecular targets.
LB  - PUB:(DE-HGF)16
C6  - pmid:30747205
UR  - <Go to ISI:>//WOS:000460780300020
DO  - DOI:10.1039/C8DT04996C
UR  - https://juser.fz-juelich.de/record/861160
ER  -