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@ARTICLE{Brandt:861160,
      author       = {Brandt, Marie R. and Vanasschen, Christian and Ermert,
                      Johannes and Coenen, Heinz H. and Neumaier, Bernd},
      title        = {52g/55{M}n-{L}abelled {CDTA}-based trimeric complexes as
                      novel bimodal {PET}/{MR} probes with high relaxivity},
      journal      = {Dalton transactions},
      volume       = {48},
      number       = {9},
      issn         = {0300-9246},
      address      = {London},
      publisher    = {Soc.},
      reportid     = {FZJ-2019-01710},
      pages        = {3003 - 3008},
      year         = {2019},
      abstract     = {Trans-1,2-diaminocyclohexane-N,N,N‘,N‘-tetraacetic acid
                      (CDTA) labelled with a mixture of paramagnetic 55Mn(II) and
                      β+-emitting 52gMn(II) offers access to bimodal Positron
                      Emission Tomography /Magnetic Resonance (PET/MR) tracers. To
                      enhance the number of NMR-active nuclei and simultaneously
                      improve the longitudinal relaxivity r1, a complex composed
                      of three CDTA units was designed. Accordingly, a
                      functionalised tris-CDTA-1,3,5-tris-triazolobenzene was
                      prepared and labelled with c.a. and n.c.a. 52gMn. Relaxivity
                      measurements of the 55Mn-complex showed an enhancement of r1
                      of $144\%$ in comparison to the Mn-CDTA monomer. Moreover,
                      the trimer was equipped with an additional linker
                      functionality suitable for conjugation with biomolecules,
                      enabling interaction with specific molecular targets.},
      cin          = {INM-5},
      ddc          = {540},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30747205},
      UT           = {WOS:000460780300020},
      doi          = {10.1039/C8DT04996C},
      url          = {https://juser.fz-juelich.de/record/861160},
}