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| Hauptseite > Publikationsdatenbank > 52g/55Mn-Labelled CDTA-based trimeric complexes as novel bimodal PET/MR probes with high relaxivity > print |
| Hauptseite > Publikationsdatenbank > 52g/55Mn-Labelled CDTA-based trimeric complexes as novel bimodal PET/MR probes with high relaxivity > print |
| 001 | 861160 | ||
| 005 | 20210130000730.0 | ||
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| 100 | 1 | _ | |a Brandt, Marie R. |0 P:(DE-Juel1)162273 |b 0 |
| 245 | _ | _ | |a 52g/55Mn-Labelled CDTA-based trimeric complexes as novel bimodal PET/MR probes with high relaxivity |
| 260 | _ | _ | |a London |c 2019 |b Soc. |
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| 520 | _ | _ | |a Trans-1,2-diaminocyclohexane-N,N,N‘,N‘-tetraacetic acid (CDTA) labelled with a mixture of paramagnetic 55Mn(II) and β+-emitting 52gMn(II) offers access to bimodal Positron Emission Tomography /Magnetic Resonance (PET/MR) tracers. To enhance the number of NMR-active nuclei and simultaneously improve the longitudinal relaxivity r1, a complex composed of three CDTA units was designed. Accordingly, a functionalised tris-CDTA-1,3,5-tris-triazolobenzene was prepared and labelled with c.a. and n.c.a. 52gMn. Relaxivity measurements of the 55Mn-complex showed an enhancement of r1 of 144% in comparison to the Mn-CDTA monomer. Moreover, the trimer was equipped with an additional linker functionality suitable for conjugation with biomolecules, enabling interaction with specific molecular targets. |
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| 700 | 1 | _ | |a Vanasschen, Christian |0 P:(DE-Juel1)157902 |b 1 |
| 700 | 1 | _ | |a Ermert, Johannes |0 P:(DE-Juel1)131818 |b 2 |e Corresponding author |
| 700 | 1 | _ | |a Coenen, Heinz H. |0 0000-0002-3810-103X |b 3 |
| 700 | 1 | _ | |a Neumaier, Bernd |0 P:(DE-Juel1)166419 |b 4 |
| 773 | _ | _ | |a 10.1039/C8DT04996C |g Vol. 48, no. 9, p. 3003 - 3008 |0 PERI:(DE-600)1472887-4 |n 9 |p 3003 - 3008 |t Dalton transactions |v 48 |y 2019 |x 0300-9246 |
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