TY  - JOUR
AU  - Worthoff, Wieland A.
AU  - Shymanskaya, Aliaksandra
AU  - Shah, N. J.
TI  - Relaxometry and quantification in simultaneously acquired single and triple quantum filtered sodium MRI
JO  - Magnetic resonance in medicine
VL  - 81
IS  - 1
SN  - 0740-3194
CY  - New York, NY [u.a.]
PB  - Wiley-Liss
M1  - FZJ-2019-02022
SP  - 303 - 315
PY  - 2019
AB  - PurposeSodium imaging delivers valuable information about in vivo metabolism and pathophysiology. Image quantification can benefit the diagnosis and characterization of existing pathologies and the clinical course of a disease. An enhanced SISTINA sequence is proposed for sodium imaging and for the estimation of sodium tissue parameters for a 2‐compartment model of the brain, such as relaxation times in intracellular space and tissue, intracellular volume fraction, and intracellular molar fraction. The aim of the research is to demonstrate how a 2‐compartment model can be parameterized to sufficiently describe tissue sodium concentrations and dynamics by performing relaxometry with such a sequence.MethodsMultiple quantum filtered sodium signals were detected using an enhanced SISTINA sequence (consisting of 3 consecutive RF pulses) by placing a readout train between the first and second RF pulse, and 1 after the third pulse. Semiautomatic segmentation using singular value decomposition and manual segmentation was applied to the images.ResultsAnalysis was performed on 40 healthy volunteers in a 4T scanner, yielding bi‐exponential relaxation times of brain tissue, intracellular sodium molar and volume fraction, intracellular sodium concentration, as well as sodium tissue concentration in the scope of a considered model. Two models with either purely mono‐exponential or bi‐exponential relaxing extracellular sodium were used with and without a potential contribution of triple quantum‐filtered signal from extracellular space.ConclusionAn estimation of relaxation properties and concentrations limited to the assumed model is possible from a single sequence. The achieved results agree well with those reported in literature.
LB  - PUB:(DE-HGF)16
C6  - pmid:30058202
UR  - <Go to ISI:>//WOS:000454009000023
DO  - DOI:10.1002/mrm.27387
UR  - https://juser.fz-juelich.de/record/861571
ER  -