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| Home > Publications database > Relaxometry and quantification in simultaneously acquired single and triple quantum filtered sodium MRI |
| Journal Article | FZJ-2019-02022 |
; ;
2019
Wiley-Liss
New York, NY [u.a.]
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Please use a persistent id in citations: doi:10.1002/mrm.27387
Abstract: PurposeSodium imaging delivers valuable information about in vivo metabolism and pathophysiology. Image quantification can benefit the diagnosis and characterization of existing pathologies and the clinical course of a disease. An enhanced SISTINA sequence is proposed for sodium imaging and for the estimation of sodium tissue parameters for a 2‐compartment model of the brain, such as relaxation times in intracellular space and tissue, intracellular volume fraction, and intracellular molar fraction. The aim of the research is to demonstrate how a 2‐compartment model can be parameterized to sufficiently describe tissue sodium concentrations and dynamics by performing relaxometry with such a sequence.MethodsMultiple quantum filtered sodium signals were detected using an enhanced SISTINA sequence (consisting of 3 consecutive RF pulses) by placing a readout train between the first and second RF pulse, and 1 after the third pulse. Semiautomatic segmentation using singular value decomposition and manual segmentation was applied to the images.ResultsAnalysis was performed on 40 healthy volunteers in a 4T scanner, yielding bi‐exponential relaxation times of brain tissue, intracellular sodium molar and volume fraction, intracellular sodium concentration, as well as sodium tissue concentration in the scope of a considered model. Two models with either purely mono‐exponential or bi‐exponential relaxing extracellular sodium were used with and without a potential contribution of triple quantum‐filtered signal from extracellular space.ConclusionAn estimation of relaxation properties and concentrations limited to the assumed model is possible from a single sequence. The achieved results agree well with those reported in literature.
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