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| Hauptseite > Publikationsdatenbank > Relaxometry and quantification in simultaneously acquired single and triple quantum filtered sodium MRI > print |
| Hauptseite > Publikationsdatenbank > Relaxometry and quantification in simultaneously acquired single and triple quantum filtered sodium MRI > print |
| 001 | 861571 | ||
| 005 | 20210130000854.0 | ||
| 024 | 7 | _ | |a 10.1002/mrm.27387 |2 doi |
| 024 | 7 | _ | |a 0740-3194 |2 ISSN |
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| 037 | _ | _ | |a FZJ-2019-02022 |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Worthoff, Wieland A. |0 P:(DE-Juel1)156200 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Relaxometry and quantification in simultaneously acquired single and triple quantum filtered sodium MRI |
| 260 | _ | _ | |a New York, NY [u.a.] |c 2019 |b Wiley-Liss |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a PurposeSodium imaging delivers valuable information about in vivo metabolism and pathophysiology. Image quantification can benefit the diagnosis and characterization of existing pathologies and the clinical course of a disease. An enhanced SISTINA sequence is proposed for sodium imaging and for the estimation of sodium tissue parameters for a 2‐compartment model of the brain, such as relaxation times in intracellular space and tissue, intracellular volume fraction, and intracellular molar fraction. The aim of the research is to demonstrate how a 2‐compartment model can be parameterized to sufficiently describe tissue sodium concentrations and dynamics by performing relaxometry with such a sequence.MethodsMultiple quantum filtered sodium signals were detected using an enhanced SISTINA sequence (consisting of 3 consecutive RF pulses) by placing a readout train between the first and second RF pulse, and 1 after the third pulse. Semiautomatic segmentation using singular value decomposition and manual segmentation was applied to the images.ResultsAnalysis was performed on 40 healthy volunteers in a 4T scanner, yielding bi‐exponential relaxation times of brain tissue, intracellular sodium molar and volume fraction, intracellular sodium concentration, as well as sodium tissue concentration in the scope of a considered model. Two models with either purely mono‐exponential or bi‐exponential relaxing extracellular sodium were used with and without a potential contribution of triple quantum‐filtered signal from extracellular space.ConclusionAn estimation of relaxation properties and concentrations limited to the assumed model is possible from a single sequence. The achieved results agree well with those reported in literature. |
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| 700 | 1 | _ | |a Shah, N. J. |0 P:(DE-Juel1)131794 |b 2 |u fzj |
| 773 | _ | _ | |a 10.1002/mrm.27387 |g Vol. 81, no. 1, p. 303 - 315 |0 PERI:(DE-600)1493786-4 |n 1 |p 303 - 315 |t Magnetic resonance in medicine |v 81 |y 2019 |x 0740-3194 |
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