TY  - JOUR
AU  - Ghosh Moulick, Ranjita
AU  - Panaitov, Gregor
AU  - Choi, Sung-Eun
AU  - Mayer, Dirk
AU  - Offenhäusser, Andreas
TI  - Patterning artificial lipid bilayer on nanostructured surfaces
JO  - International journal of nanomedicine
VL  -  13
SN  - 1178-2013
CY  - Auckland
PB  - DOVE Medical Press
M1  - FZJ-2019-02030
SP  - 55 - 58
PY  - 2018
AB  - Artificial lipid bilayer on solid substrate plays an important role as an interface between nanotechnology and biology. In this study, grid structures were patterned on Au-Nb-glass substrate and artificial bilayer was prepared on these structures. The fluidity was checked using fluorescence recovery after photobleaching (FRAP), and neuronal adhesion was monitored on such structure using EphrinA5-tethered lipid bilayer. EphrinA5 is a ligand that binds to the Eph receptors of rat cortical neurons and influences cellular adhesion. Our result elucidated that influence of these nanopatterned protein-tethered lipid bilayer on cellular guidance and signaling can address many underlying mechanisms of cellular functioning and help us to understand and differentiate the signaling procedure in cancer and neurodegenerative diseases.
LB  - PUB:(DE-HGF)16
C6  - pmid:29593396
DO  - DOI:10.2147/IJN.S125005
UR  - https://juser.fz-juelich.de/record/861579
ER  -