Journal Article

FZJ-2019-02030

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Patterning artificial lipid bilayer on nanostructured surfaces

Ghosh Moulick, R. (Corresponding author) ; Panaitov, G.FZJ* ; Choi, S.-E. ; Mayer, D.FZJ* ; Offenhäusser, A.FZJ*

2018
DOVE Medical Press Auckland

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Please use a persistent id in citations: http://hdl.handle.net/2128/22012  doi:10.2147/IJN.S125005

Abstract: Artificial lipid bilayer on solid substrate plays an important role as an interface between nanotechnology and biology. In this study, grid structures were patterned on Au-Nb-glass substrate and artificial bilayer was prepared on these structures. The fluidity was checked using fluorescence recovery after photobleaching (FRAP), and neuronal adhesion was monitored on such structure using EphrinA5-tethered lipid bilayer. EphrinA5 is a ligand that binds to the Eph receptors of rat cortical neurons and influences cellular adhesion. Our result elucidated that influence of these nanopatterned protein-tethered lipid bilayer on cellular guidance and signaling can address many underlying mechanisms of cellular functioning and help us to understand and differentiate the signaling procedure in cancer and neurodegenerative diseases.

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Contributing Institute(s):

1. Bioelektronik (ICS-8)

Research Program(s):

1. 552 - Engineering Cell Function (POF3-552) (POF3-552)

Appears in the scientific report 2019

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Database coverage:
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