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@ARTICLE{Kireev:862097,
      author       = {Kireev, Dmitry and Rincon-Montes, V. and Stevanovic, Jelena
                      and Srikantharajah, Kagithiri and Offenhäusser, Andreas},
      title        = {{N}3-{MEA} probes: {S}cooping {N}euronal {N}etworks},
      journal      = {Frontiers in neuroscience},
      volume       = {13},
      issn         = {1662-453X},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2019-02453},
      pages        = {320},
      year         = {2019},
      abstract     = {In the current work, we introduce a brand new line of
                      versatile, flexible, and multifunctional MEA probes, the
                      so-called Nano Neuro Net, or N3-MEAs. Material choice,
                      dimensions, and room for further upgrade, were carefully
                      considered when designing such probes in order to cover the
                      widest application range possible. Proof of the operation
                      principle of these novel probes is shown in the manuscript
                      via the recording of extracellular signals, such as action
                      potentials and local field potentials from cardiac cells and
                      retinal ganglion cells of the heart tissue and eye
                      respectively. Reasonably large signal to noise ratio (SNR)
                      combined with effortless operation of the devices,
                      mechanical and chemical stability, multifunctionality
                      provide, in our opinion, an unprecedented blend. We show
                      successful recordings of (1) action potentials from heart
                      tissue with a SNR up to 13.2; (2) spontaneous activity of
                      retinal ganglion cells with a SNR up to 12.8; and (3) local
                      field potentials with an ERG-like waveform, as well as
                      spiking responses of the retina to light stimulation. The
                      results reveal not only the multi-functionality of these
                      N3-MEAs, but high quality recordings of electrogenic
                      tissues.},
      cin          = {ICS-8},
      ddc          = {610},
      cid          = {I:(DE-Juel1)ICS-8-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31024239},
      UT           = {WOS:000464445500001},
      doi          = {10.3389/fnins.2019.00320},
      url          = {https://juser.fz-juelich.de/record/862097},
}