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@ARTICLE{deSaintVictor:862255,
author = {de Saint Victor, Marie and Barnsley, Lester C. and Carugo,
Dario and Owen, Joshua and Coussios, Constantin C. and
Stride, Eleanor},
title = {{S}onothrombolysis with {M}agnetically {T}argeted
{M}icrobubbles},
journal = {Ultrasound in medicine $\&$ biology},
volume = {45},
number = {5},
issn = {0301-5629},
address = {Amsterdam [u.a.]},
publisher = {Elsevier Science},
reportid = {FZJ-2019-02597},
pages = {1151 - 1163},
year = {2019},
abstract = {Microbubble-enhanced sonothrombolysis is a promising
approach to increasing the tolerability and efficacy of
current pharmacological treatments for ischemic stroke.
Maintaining therapeutic concentrations of microbubbles and
drugs at the clot site, however, poses a challenge. The
objective of this study was to investigate the effect of
magnetic microbubble targeting upon clot lysis rates in
vitro. Retracted whole porcine blood clots were placed in a
flow phantom of a partially occluded middle cerebral artery.
The clots were treated with a combination of tissue
plasminogen activator (0.75 µg/mL), magnetic microbubbles
(∼107 microbubbles/mL) and ultrasound (0.5 MHz, 630-kPa
peak rarefactional pressure, 0.2-Hz pulse repetition
frequency, $2\%$ duty cycle). Magnetic targeting was
achieved using a single permanent magnet (0.08–0.38 T and
12-140 T/m in the region of the clot). The change in clot
diameter was measured optically over the course of the
experiment. Magnetic targeting produced a threefold average
increase in lysis rates, and linear correlation was observed
between lysis rate and total energy of acoustic emissions.},
cin = {JCNS-FRM-II / JCNS-1 / MLZ},
ddc = {570},
cid = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
I:(DE-Juel1)JCNS-1-20110106 / I:(DE-588b)4597118-3},
pnm = {6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
/ 6G15 - FRM II / MLZ (POF3-6G15)},
pid = {G:(DE-HGF)POF3-6G4 / G:(DE-HGF)POF3-6G15},
experiment = {EXP:(DE-MLZ)NOSPEC-20140101},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:30773375},
UT = {WOS:000464126800011},
doi = {10.1016/j.ultrasmedbio.2018.12.014},
url = {https://juser.fz-juelich.de/record/862255},
}