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@ARTICLE{deSaintVictor:862255,
      author       = {de Saint Victor, Marie and Barnsley, Lester C. and Carugo,
                      Dario and Owen, Joshua and Coussios, Constantin C. and
                      Stride, Eleanor},
      title        = {{S}onothrombolysis with {M}agnetically {T}argeted
                      {M}icrobubbles},
      journal      = {Ultrasound in medicine $\&$ biology},
      volume       = {45},
      number       = {5},
      issn         = {0301-5629},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2019-02597},
      pages        = {1151 - 1163},
      year         = {2019},
      abstract     = {Microbubble-enhanced sonothrombolysis is a promising
                      approach to increasing the tolerability and efficacy of
                      current pharmacological treatments for ischemic stroke.
                      Maintaining therapeutic concentrations of microbubbles and
                      drugs at the clot site, however, poses a challenge. The
                      objective of this study was to investigate the effect of
                      magnetic microbubble targeting upon clot lysis rates in
                      vitro. Retracted whole porcine blood clots were placed in a
                      flow phantom of a partially occluded middle cerebral artery.
                      The clots were treated with a combination of tissue
                      plasminogen activator (0.75 µg/mL), magnetic microbubbles
                      (∼107 microbubbles/mL) and ultrasound (0.5 MHz, 630-kPa
                      peak rarefactional pressure, 0.2-Hz pulse repetition
                      frequency, $2\%$ duty cycle). Magnetic targeting was
                      achieved using a single permanent magnet (0.08–0.38 T and
                      12-140 T/m in the region of the clot). The change in clot
                      diameter was measured optically over the course of the
                      experiment. Magnetic targeting produced a threefold average
                      increase in lysis rates, and linear correlation was observed
                      between lysis rate and total energy of acoustic emissions.},
      cin          = {JCNS-FRM-II / JCNS-1 / MLZ},
      ddc          = {570},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106 / I:(DE-588b)4597118-3},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
                      / 6G15 - FRM II / MLZ (POF3-6G15)},
      pid          = {G:(DE-HGF)POF3-6G4 / G:(DE-HGF)POF3-6G15},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30773375},
      UT           = {WOS:000464126800011},
      doi          = {10.1016/j.ultrasmedbio.2018.12.014},
      url          = {https://juser.fz-juelich.de/record/862255},
}