%0 Journal Article
%A Karrer, Teresa M.
%A Bassett, Danielle S.
%A Derntl, Birgit
%A Gruber, Oliver
%A Aleman, André
%A Jardri, Renaud
%A Laird, Angela R.
%A Fox, Peter T.
%A Eickhoff, Simon
%A Grisel, Olivier
%A Varoquaux, Gaël
%A Thirion, Bertrand
%A Bzdok, Danilo
%T Brain‐based ranking of cognitive domains to predict schizophrenia
%J Human brain mapping
%V 40
%N 15
%@ 1097-0193
%C New York, NY
%I Wiley-Liss
%M FZJ-2019-04012
%P 4487-4507
%D 2019
%Z Deutsche Forschungsgemeinschaft, Grant/Award Numbers: BZ2/2-1, BZ2/3-1, BZ2/4-1;Paul Allen Foundation; John D. and CatherineT. MacArthur Foundation; Alfred P. SloanFoundation; ISI Foundation; ExploratoryResearch Space, Grant/Award Number:OPSF449; START-Program of the Faculty ofMedicine, Grant/Award Number: 126/16;Amazon AWS Research Grant; InternationalResearch Training Group, Grant/AwardNumber: IRTG2150
%X Schizophrenia is a devastating brain disorder that disturbs sensory perception, motoraction, and abstract thought. Its clinical phenotype implies dysfunction of variousmental domains, which has motivated a series of theories regarding the underlyingpathophysiology. Aiming at a predictive benchmark of a catalog of cognitive functions,we developed a data-driven machine-learning strategy and provide a proof ofprinciple in a multisite clinical dataset (n = 324). Existing neuroscientific knowledge ondiverse cognitive domains was first condensed into neurotopographical maps. Wethen examined how the ensuing meta-analytic cognitive priors can distinguishpatients and controls using brain morphology and intrinsic functional connectivity.Some affected cognitive domains supported well-studied directions of research onauditory evaluation and social cognition. However, rarely suspected cognitivedomains also emerged as disease relevant, including self-oriented processing of bodilysensations in gustation and pain. Such algorithmic charting of the cognitive landscapecan be used to make targeted recommendations for future mental health research.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31313451
%U <Go to ISI:>//WOS:000476081600001
%R 10.1002/hbm.24716
%U https://juser.fz-juelich.de/record/864112