Journal Article

FZJ-2019-04012

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Brain‐based ranking of cognitive domains to predict schizophrenia

Karrer, T. M. ; Bassett, D. S. ; Derntl, B. ; Gruber, O. ; Aleman, A. ; Jardri, R. ; Laird, A. R. ; Fox, P. T. ; Eickhoff, S.FZJ* ; Grisel, O. ; Varoquaux, G. ; Thirion, B. ; Bzdok, D. (Corresponding author)

2019
Wiley-Liss New York, NY

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Please use a persistent id in citations: http://hdl.handle.net/2128/23670  doi:10.1002/hbm.24716

Abstract: Schizophrenia is a devastating brain disorder that disturbs sensory perception, motoraction, and abstract thought. Its clinical phenotype implies dysfunction of variousmental domains, which has motivated a series of theories regarding the underlyingpathophysiology. Aiming at a predictive benchmark of a catalog of cognitive functions,we developed a data-driven machine-learning strategy and provide a proof ofprinciple in a multisite clinical dataset (n = 324). Existing neuroscientific knowledge ondiverse cognitive domains was first condensed into neurotopographical maps. Wethen examined how the ensuing meta-analytic cognitive priors can distinguishpatients and controls using brain morphology and intrinsic functional connectivity.Some affected cognitive domains supported well-studied directions of research onauditory evaluation and social cognition. However, rarely suspected cognitivedomains also emerged as disease relevant, including self-oriented processing of bodilysensations in gustation and pain. Such algorithmic charting of the cognitive landscapecan be used to make targeted recommendations for future mental health research.

Note: Deutsche Forschungsgemeinschaft, Grant/Award Numbers: BZ2/2-1, BZ2/3-1, BZ2/4-1;Paul Allen Foundation; John D. and CatherineT. MacArthur Foundation; Alfred P. SloanFoundation; ISI Foundation; ExploratoryResearch Space, Grant/Award Number:OPSF449; START-Program of the Faculty ofMedicine, Grant/Award Number: 126/16;Amazon AWS Research Grant; InternationalResearch Training Group, Grant/AwardNumber: IRTG2150

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 572 - (Dys-)function and Plasticity (POF3-572) (POF3-572)

Appears in the scientific report 2019

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Database coverage:
; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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