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@ARTICLE{Karrer:864112,
author = {Karrer, Teresa M. and Bassett, Danielle S. and Derntl,
Birgit and Gruber, Oliver and Aleman, André and Jardri,
Renaud and Laird, Angela R. and Fox, Peter T. and Eickhoff,
Simon and Grisel, Olivier and Varoquaux, Gaël and Thirion,
Bertrand and Bzdok, Danilo},
title = {{B}rain‐based ranking of cognitive domains to predict
schizophrenia},
journal = {Human brain mapping},
volume = {40},
number = {15},
issn = {1097-0193},
address = {New York, NY},
publisher = {Wiley-Liss},
reportid = {FZJ-2019-04012},
pages = {4487-4507},
year = {2019},
note = {Deutsche Forschungsgemeinschaft, Grant/Award Numbers:
BZ2/2-1, BZ2/3-1, BZ2/4-1;Paul Allen Foundation; John D. and
CatherineT. MacArthur Foundation; Alfred P. SloanFoundation;
ISI Foundation; ExploratoryResearch Space, Grant/Award
Number:OPSF449; START-Program of the Faculty ofMedicine,
Grant/Award Number: 126/16;Amazon AWS Research Grant;
InternationalResearch Training Group, Grant/AwardNumber:
IRTG2150},
abstract = {Schizophrenia is a devastating brain disorder that disturbs
sensory perception, motoraction, and abstract thought. Its
clinical phenotype implies dysfunction of variousmental
domains, which has motivated a series of theories regarding
the underlyingpathophysiology. Aiming at a predictive
benchmark of a catalog of cognitive functions,we developed a
data-driven machine-learning strategy and provide a proof
ofprinciple in a multisite clinical dataset (n = 324).
Existing neuroscientific knowledge ondiverse cognitive
domains was first condensed into neurotopographical maps.
Wethen examined how the ensuing meta-analytic cognitive
priors can distinguishpatients and controls using brain
morphology and intrinsic functional connectivity.Some
affected cognitive domains supported well-studied directions
of research onauditory evaluation and social cognition.
However, rarely suspected cognitivedomains also emerged as
disease relevant, including self-oriented processing of
bodilysensations in gustation and pain. Such algorithmic
charting of the cognitive landscapecan be used to make
targeted recommendations for future mental health research.},
cin = {INM-7},
ddc = {610},
cid = {I:(DE-Juel1)INM-7-20090406},
pnm = {572 - (Dys-)function and Plasticity (POF3-572)},
pid = {G:(DE-HGF)POF3-572},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:31313451},
UT = {WOS:000476081600001},
doi = {10.1002/hbm.24716},
url = {https://juser.fz-juelich.de/record/864112},
}