Hauptseite > Publikationsdatenbank > Brain‐based ranking of cognitive domains to predict schizophrenia > print

001     864112
005     20210130002433.0
024 7 _ |a 10.1002/hbm.24716
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037 _ _ |a FZJ-2019-04012
082 _ _ |a 610
100 1 _ |a Karrer, Teresa M.
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245 _ _ |a Brain‐based ranking of cognitive domains to predict schizophrenia
260 _ _ |a New York, NY
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500 _ _ |a Deutsche Forschungsgemeinschaft, Grant/Award Numbers: BZ2/2-1, BZ2/3-1, BZ2/4-1;Paul Allen Foundation; John D. and CatherineT. MacArthur Foundation; Alfred P. SloanFoundation; ISI Foundation; ExploratoryResearch Space, Grant/Award Number:OPSF449; START-Program of the Faculty ofMedicine, Grant/Award Number: 126/16;Amazon AWS Research Grant; InternationalResearch Training Group, Grant/AwardNumber: IRTG2150
520 _ _ |a Schizophrenia is a devastating brain disorder that disturbs sensory perception, motoraction, and abstract thought. Its clinical phenotype implies dysfunction of variousmental domains, which has motivated a series of theories regarding the underlyingpathophysiology. Aiming at a predictive benchmark of a catalog of cognitive functions,we developed a data-driven machine-learning strategy and provide a proof ofprinciple in a multisite clinical dataset (n = 324). Existing neuroscientific knowledge ondiverse cognitive domains was first condensed into neurotopographical maps. Wethen examined how the ensuing meta-analytic cognitive priors can distinguishpatients and controls using brain morphology and intrinsic functional connectivity.Some affected cognitive domains supported well-studied directions of research onauditory evaluation and social cognition. However, rarely suspected cognitivedomains also emerged as disease relevant, including self-oriented processing of bodilysensations in gustation and pain. Such algorithmic charting of the cognitive landscapecan be used to make targeted recommendations for future mental health research.
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700 1 _ |a Bassett, Danielle S.
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700 1 _ |a Derntl, Birgit
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700 1 _ |a Gruber, Oliver
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700 1 _ |a Aleman, André
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700 1 _ |a Jardri, Renaud
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700 1 _ |a Laird, Angela R.
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700 1 _ |a Fox, Peter T.
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700 1 _ |a Eickhoff, Simon
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700 1 _ |a Grisel, Olivier
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700 1 _ |a Varoquaux, Gaël
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700 1 _ |a Thirion, Bertrand
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700 1 _ |a Bzdok, Danilo
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773 _ _ |a 10.1002/hbm.24716
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856 4 _ |y Published on 2019-07-16. Available in OpenAccess from 2020-07-16.
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856 4 _ |y Published on 2019-07-16. Available in OpenAccess from 2020-07-16.
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