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VirtualBrainCloud

Personalized Recommendations for Neurodegenerative Disease

CoordinatorCODEBOX COMPUTER-DIENSTE GMBH ; EODYNE SYSTEMS SL ; TP21 GMBH ; CODEMART SRL ; INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE ; Forschungszentrum Jülich ; Universitätszahnklinik Wien ; University of Genoa ; FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ; Aix-Marseille University ; THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD ; Alzheimer Europe ; HELSINGIN YLIOPISTO ; INSTITUT NATIONAL DE RECHERCHE ENINFORMATIQUE ET AUTOMATIQUE ; Complutense University of Madrid ; FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. ; Charité Universitätsmedizin Berlin
Grant period2018-12-01 - 2023-05-31
Funding bodyEuropean Union
Call numberH2020-SC1-DTH-2018-1
Grant number826421
IdentifierG:(EU-Grant)826421

Note: The annual worldwide cost of Alzheimer’s dementia was 777.81 billion Euro in 2015. This number will rise to 7.41 trillion Euro in 2050. Early diagnosis would save up to $7.9 trillion in medical and care costs by 2050 in the US alone. However, the emergent pathology is highly variable across people, necehighly variable across people, necessitating individualized diagnostics and interventions. The VirtualBrainCloud addresses this by bridging the gap between computational neuroscience and subcellular systems biology, integrating both research streams into a unifying computational model that supports personalized diagnostics and treatments in NDD. TheVirtualBrainCloud not only integrates existing software tools, it also merges the efforts of two big EU initiatives, namely The Virtual Brain large scale simulation platform of the EU Flagship Human Brain Project and IMI-EPAD initiative (European prevention of Alzheimer’s dementia consortium). VirtualBrainCloud will develop and validate a decision support system that provides access to high quality multi-disciplinary data for clinical practice. The result will be a cloud-based brain simulation platform to support personalized diagnostics and treatments in NDD. The EU PRACE (Partnership for Advanced Computing in Europe) initiative, will provide the required computing infrastructure. The VirtualBrainCloud will develop robust solutions for legal and ethical matters by interacting with EU projects such as European Open Science Cloud (EOSC), ‘cloud4health’, Alzheimer’s Europe patient organizations and ELIXIR, an organization that manages and safeguards EU research data. Our software developers have already produced highly successful brain simulation and clinical decision support tools. The resulting software will be a cloud based computational modeling system that is tailored to the individual, and bridges multiple scales to identify key mechanisms that predict NDD progression and serves as Precision Decision Support System.
     

Recent Publications

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http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Preprint  ;  ;  ;
Effective workflow from multi-modal MRI data to model-based prediction
[10.31219/osf.io/67zxe] OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Preprint  ;  ;  ;
Simulated brain networks reflecting progression of Parkinson’s disease
bioRxiv beta () [10.1101/2024.01.12.574450] OpenAccess  Download fulltext Files  Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Poster (After Call)  ;  ;  ;  ;  ;
Impact of data processing on DCM estimates of effective connectivity from task-evoked fMRI
The 29th Annual Meeting of the Organization for Human Brain Mapping, OHBM2023, MontrealMontreal, Canada, 22 Jul 2023 - 26 Jul 20232023-07-222023-07-26 [10.34734/FZJ-2024-01235] OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Poster (Outreach)  ;  ;  ;  ;  ;
Simulation and Data Lab Neuroscience - Bridging Neuroscience and HPC
Bernstein Conference for Computational Neuroscience, BerlinBerlin, Germany, 27 Sep 2023 - 29 Sep 20232023-09-272023-09-29 BibTeX | EndNote: XML, Text | RIS

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Poster (Outreach)  ;  ;  ;  ;  ;
Simulation and Data Lab Neuroscience - Bridging Neuroscience and HPC
International Conference for High Performance Computing, Networking, Storage, and Analysis, SC23, DenverDenver, USA, 12 Nov 2023 - 17 Nov 20232023-11-122023-11-17 BibTeX | EndNote: XML, Text | RIS

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Poster (After Call)  ;  ;
Validation of dynamical whole-brain models in high-dimensional parameter spaces
The 29th Annual Meeting of the Organization for Human Brain Mapping (OHBM2023), HHU DüsseldorfMontréal, HHU Düsseldorf, Canada, 22 Jul 2023 - 26 Jul 20232023-07-222023-07-26 [10.34734/FZJ-2023-04546] OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Poster (After Call)  ;  ;  ;  ;
Dynamic causal modeling computational pipeline for resting-state fMRI data: the structure and main modules for DCM and PEB analysis
INM Retreat, JülichJülich, Germany, 17 Oct 2023 - 18 Oct 20232023-10-172023-10-18 [10.34734/FZJ-2023-04125] OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Poster (After Call)  ;  ;  ;  ;  ;  ;
Whole-brain dynamical modeling for classification of Parkinson's disease
Organization for Human Brain Mapping (OHBM), MontrealMontreal, Canada, 22 Jul 2023 - 26 Jul 20232023-07-222023-07-26 [10.34734/FZJ-2023-03046] OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Poster (After Call)  ;  ;
Reliability and subject specificity of personalized dynamical whole-brain models
NIC Symposium 2022, JülichJülich, Germany, 29 Sep 2022 - 30 Sep 20222022-09-292022-09-30 OpenAccess  Download fulltext Files  Download fulltextFulltext Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Poster (Other)  ;  ;
Validation of dynamical whole-brain models in high-dimensional spaces
INM & IBI Retreat 2022 "Molecular neuroscience meets brain function", JülichJülich, Germany, 18 Oct 2022 - 19 Oct 20222022-10-182022-10-19 OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

All known publications ...
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 Datensatz erzeugt am 2019-07-30, letzte Änderung am 2023-02-07
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