%0 Journal Article
%A Schmitz, Ann Kristin
%A Sorg, Rüdiger V.
%A Stoffels, Gabriele
%A Grauer, Oliver M.
%A Galldiks, Norbert
%A Steiger, Hans-Jakob
%A Kamp, Marcel A.
%A Langen, Karl-Josef
%A Sabel, Michael
%A Rapp, Marion
%T Diagnostic impact of additional O-(2-[18F]fluoroethyl)-L-tyrosine ( 18 F-FET) PET following immunotherapy with dendritic cell vaccination in glioblastoma patients
%J British journal of neurosurgery
%V 35
%N 6
%@ 1360-046X
%C London [u.a.]
%I Taylor & Francis
%M FZJ-2019-04251
%P 736-742
%D 2021
%X Objective: Vaccination therapy using tumour antigen-loaded, autologous dendritic cells (DC) is a promising therapeutic approach alongside standard treatment for glioblastoma (GBM). However, reliable diagnostic criteria regarding therapy monitoring are not established. Here, we analysed the impact of additional 18F-fluoroethyl-tyrosine positron emission tomography (18F-FET PET) imaging following DC vaccination therapy.Methods: We analysed data of GBM patients who received DC vaccination therapy. Following MRI diagnosis of tumour recurrence, additional static and dynamic 18F-FET PET imaging was performed. Vaccination was performed five times by intradermal injections, either weekly between concomitant radio/-chemotherapy and intermittent chemotherapy or after tumour recurrence, before re-radiation therapy. MRI and 18F-FET PET results were compared and correlated with clinical data.Results: Between 2003 and 2016, 5 patients were identified who received DC vaccination and 18F-FET PET imaging (1 female/4 males; mean age: 44 ± 14 y). 3/5 patients showed congruent results of tumour progression. In three patients 18F-FET PET indicated treatment related changes, which was in contrast to MRI findings that indicated tumour progression. In these patients 18F-FET PET results could be confirmed by either neuropathological diagnosis or according to the RANO criteriaConclusions: Despite the small patients number our results indicate an additional impact of 18F-FET PET for monitoring outcome following vaccination therapy.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 31407920
%U <Go to ISI:>//WOS:000480905300001
%R 10.1080/02688697.2019.1639615
%U https://juser.fz-juelich.de/record/864473