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| 024 | 7 | _ | |a 10.1080/02688697.2019.1639615 |2 doi |
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| 100 | 1 | _ | |a Schmitz, Ann Kristin |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Diagnostic impact of additional O-(2-[18F]fluoroethyl)-L-tyrosine ( 18 F-FET) PET following immunotherapy with dendritic cell vaccination in glioblastoma patients |
| 260 | _ | _ | |a London [u.a.] |c 2021 |b Taylor & Francis |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Objective: Vaccination therapy using tumour antigen-loaded, autologous dendritic cells (DC) is a promising therapeutic approach alongside standard treatment for glioblastoma (GBM). However, reliable diagnostic criteria regarding therapy monitoring are not established. Here, we analysed the impact of additional 18F-fluoroethyl-tyrosine positron emission tomography (18F-FET PET) imaging following DC vaccination therapy.Methods: We analysed data of GBM patients who received DC vaccination therapy. Following MRI diagnosis of tumour recurrence, additional static and dynamic 18F-FET PET imaging was performed. Vaccination was performed five times by intradermal injections, either weekly between concomitant radio/-chemotherapy and intermittent chemotherapy or after tumour recurrence, before re-radiation therapy. MRI and 18F-FET PET results were compared and correlated with clinical data.Results: Between 2003 and 2016, 5 patients were identified who received DC vaccination and 18F-FET PET imaging (1 female/4 males; mean age: 44 ± 14 y). 3/5 patients showed congruent results of tumour progression. In three patients 18F-FET PET indicated treatment related changes, which was in contrast to MRI findings that indicated tumour progression. In these patients 18F-FET PET results could be confirmed by either neuropathological diagnosis or according to the RANO criteriaConclusions: Despite the small patients number our results indicate an additional impact of 18F-FET PET for monitoring outcome following vaccination therapy. |
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| 773 | _ | _ | |a 10.1080/02688697.2019.1639615 |g p. 1 - 7 |0 PERI:(DE-600)1499131-7 |n 6 |p 736-742 |t British journal of neurosurgery |v 35 |y 2021 |x 1360-046X |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/864473/files/Schmitz%20Postprint%20BJN%202019.pdf |y Published on 2019-08-13. Available in OpenAccess from 2020-08-13. |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/864473/files/Schmitz%20Postprint%20BJN%202019.pdf?subformat=pdfa |x pdfa |y Published on 2019-08-13. Available in OpenAccess from 2020-08-13. |
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