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| Home > Publications database > Fronto-striatal contributions to the control of response interference: a functional magnetic resonance imaging study. |
| Abstract | FZJ-2019-04447 |
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2019
Abstract: E34 Fronto-striatal contributions to the control of responseinterference: a functional magnetic resonance imaging studyClaudia C. Schmidt1, David C. Timpert1,2, Isabel Arend3, Simone Vossel1,4,Gereon R. Fink1,2, Avishai Henik3, Peter H. Weiss1,2; 1Cognitive Neuroscience,Institute of Neuroscience and Medicine (INM-3), Research Centre Juelich,Juelich, Germany, 2Department of Neurology, University Hospital Cologne,Cologne, Germany, 3Department of Psychology and the Zlotowski Center forNeuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel,4Department of Psychology, University of Cologne, Cologne, GermanyWhile the role of cortical regions in cognitive control processes is wellaccepted, the contribution of subcortical structures (e.g., the striatum),especially to the control of response interference, is still debated. Therefore,the present study aimed to further investigate the cortical and subcorticalneural mechanisms of response interference control. For that purpose,thirteen healthy young participants underwent event-related functionalmagnetic resonance imaging (fMRI) while performing a unimanual version ofthe Simon task. In this task, successful performance requires the resolution ofstimulus-response conflicts in incongruent trials. Behavioural results showedan asymmetrical Simon effect that was more pronounced in the contralateralhemifield. The contrast of incongruent trials compared to congruent trials (i.e.,the overall Simon effect) significantly activated clusters in the right anteriorcingulate cortex (ACC), the caudate nucleus bilaterally, and the right posteriorinsula. A regression analysis revealed that the magnitude of the contralateralSimon effect significantly co-varied with activation in the left dorsolateralprefrontal cortex (DLPFC). The current pattern of brain activationscorroborates the notion that the cognitive control of response interference issupported by a fronto-striatal network, with an essential contribution of thecaudate nucleus.Topic Area: EXECUTIVE PROCESSES: Monitoring & inhibitory control symptoms. This cognitive skill may be associated with ADHD symptomremission.Topic Area: EXECUTIVE PROCESSES: Monitoring & inhibitory control
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